Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848030 | 0.76 | TP53 (0.59) | TP53MAPTSMN1; SMN2HRH4HRH3 | |
| SCHEMBL10885287 | 0.74 | TP53 (0.56) | TP53MAPTSMN1; SMN2HRH4HRH3 | |
| SCHEMBL405269 | 0.73 | HRH4 (0.60) | TP53MAPTSMN1; SMN2HRH4HRH3 | |
| SCHEMBL10885283 | 0.73 | TP53 (0.63) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL10847842 | 0.71 | RXFP1 (0.65) | TP53MAPTSMN1; SMN2RXFP1KMT2A | |
| SCHEMBL435708 | 0.70 | MAPT (0.51) | TP53MAPTSMN1; SMN2HRH4HRH3 | |
| SCHEMBL405648 | 0.69 | HRH4 (0.53) | TP53MAPTSMN1; SMN2HRH4HRH3 | |
| SCHEMBL404420 | 0.68 | MAPT (0.65) | TP53MAPTSMN1; SMN2HRH4HRH3 | |
| SCHEMBL462880 | 0.68 | MAPT (0.51) | TP53MAPTSMN1; SMN2HRH4HRH3 | |
| SCHEMBL439933 | 0.68 | MAPT (0.51) | TP53MAPTSMN1; SMN2HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107455-A1 | Triazoloquinoxalines as antidepressants and antifatigue agents | PFIZER INC. (US) | 1984-05-02 | — | — | EP | disclosed |