Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 17/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10984766 | 0.87 | CASP1 (0.41) | CASP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21978267 | 0.84 | CASP1 (0.47) | CASP1ALDH1A1 | |
| SCHEMBL21978269 | 0.84 | CASP1 (0.47) | CASP1ALDH1A1 | |
| SCHEMBL10885200 | 0.84 | CASP1 (0.47) | CASP1ALDH1A1 | |
| SCHEMBL28385473 | 0.83 | CASP1 (0.43) | CASP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28387010 | 0.83 | CASP1 (0.43) | CASP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17919265 | 0.78 | CASP1 (0.40) | CASP1ALDH1A1MEN1KMT2A | |
| SCHEMBL10976689 | 0.77 | CASP1 (0.44) | CASP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10885419 | 0.77 | TDP1 (0.39) | CASP1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10975759 | 0.77 | CASP1 (0.44) | CASP1ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109044-B1 | PENEMS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESS FOR PREPARING THEM | SCHERING CORPORATION (US) | 1986-10-15 | — | — | EP | disclosed |
| US-4540580-A | 2-[(1'R)-1'-Aminoalkyl]penems | SCHERING CORPORATION (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0109044-A1 | Penems, pharmaceutical compositions containing them, process for preparing them | SCHERING CORPORATION (US) | 1984-05-23 | — | — | EP | disclosed |