Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27984992 | 0.93 | BLM (0.43) | BLMKDM4CKDM4APHF8KDM2A | |
| Acetic Acid SCHEMBL1427501 | 0.93 | BLM (0.43) | BLMKDM4CKDM4APHF8KDM2A | |
| SCHEMBL28582030 | 0.91 | BLM (0.47) | BLMKDM4CKDM4APHF8KDM2A | |
| SCHEMBL5498280 | 0.89 | LMNA (0.50) | BLMKDM4CKDM4APHF8KDM2A | |
| Isostearyl Alcohol SCHEMBL8716 | 0.89 | LMNA (0.50) | BLMKDM4CKDM4APHF8KDM2A | |
| SCHEMBL352004 | 0.89 | LMNA (0.50) | BLMKDM4CKDM4APHF8KDM2A | |
| SCHEMBL9620428 | 0.89 | LMNA (0.50) | BLMKDM4CKDM4APHF8KDM2A | |
| SCHEMBL20345 | 0.89 | LMNA (0.50) | BLMKDM4CKDM4APHF8KDM2A | |
| SCHEMBL3778363 | 0.89 | LMNA (0.50) | BLMKDM4CKDM4APHF8KDM2A | |
| SCHEMBL26877 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4614570-A | APPLYING ELECTRICITY TO MULTILAYED MATERIAL CONTAINING ELECTROCONDUCTIVE REPRODUCTIVE LAYERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-09-30 | — | — | US | disclosed |
| US-4549944-A | Electrochemical developing process for reproduction layers | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-10-29 | — | — | US | disclosed |