Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 2/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7157836 | 0.81 | NPSR1 (0.50) | LMNAGAANPSR1L3MBTL1MAPT | |
| SCHEMBL10890249 | 0.79 | CA1 (0.63) | LMNAGAACA1CA2MAPT | |
| SCHEMBL14773882 | 0.78 | GAA (0.56) | LMNAGAACA1CA2L3MBTL1 | |
| SCHEMBL10887875 | 0.73 | CA1 (0.66) | LMNAGAACA1CA2 | |
| SCHEMBL9689593 | 0.72 | CA1 (0.68) | LMNAGAACA1CA2MAPT | |
| SCHEMBL10886823 | 0.72 | CA1 (0.72) | LMNAGAACA1CA2L3MBTL1 | |
| SCHEMBL5713558 | 0.71 | CA1 (0.64) | LMNAGAACA1CA2L3MBTL1 | |
| SCHEMBL20092723 | 0.71 | CYP1A2 (0.55) | LMNAHSD17B10 | |
| SCHEMBL18986012 | 0.71 | TSHR (0.51) | LMNANPSR1HSD17B10 | |
| SCHEMBL15677689 | 0.70 | CA1 (0.61) | LMNAGAACA1CA2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4578390-A | SKIN DISORDERS; TOPICAL | MERCK & CO., INC. (US) | 1986-03-25 | — | — | US | disclosed |
| EP-0081782-B1 | HYDROXYBENZYLAMINO-ARYL COMPOUNDS, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1985-10-30 | — | — | EP | disclosed |
| EP-0122321-A1 | Hydroxybenzylamino derivatives as anti-inflammatory agents | MERCK & CO. INC. (US) | 1984-10-24 | — | — | EP | disclosed |
| EP-0081782-A1 | Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1983-06-22 | — | — | EP | disclosed |