Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.68 |
| ▸ | CA2 | P00918 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | ARG1 | P05089 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713558 | 0.90 | CA1 (0.64) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL10887875 | 0.86 | CA1 (0.66) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL10886823 | 0.84 | CA1 (0.72) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL10890249 | 0.83 | CA1 (0.63) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL25168125 | 0.81 | CA1 (0.64) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL10890059 | 0.81 | CA1 (0.64) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL7162593 | 0.79 | CA1 (0.64) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL5714226 | 0.79 | MAPT (0.60) | CA1CA2LMNAGAAPOLB | |
| SCHEMBL22624720 | 0.78 | LMNA (0.55) | CA1CA2LMNAGAAMAOA | |
| SCHEMBL15677689 | 0.77 | CA1 (0.61) | CA1CA2LMNAGAAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |