Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.51 |
| ▸ | CASR | P41180 | 5/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | GRK3 | P35626 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10890029 | 0.92 | HTR1A (0.54) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10897446 | 0.89 | HTR1A (0.42) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10893896 | 0.88 | SLC2A1 (0.42) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10893417 | 0.88 | HTR1A (0.61) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10892906 | 0.88 | GRK3 (0.44) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10887474 | 0.88 | GRK3 (0.46) | CYP2D6CASRADRB2ADRB3MEN1 | |
| Hydrochloric Acid SCHEMBL10891439 | 0.88 | HTR1A (0.60) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10889418 | 0.87 | CASR (0.44) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10887107 | 0.87 | CASR (0.49) | CYP2D6CASRSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL10889495 | 0.87 | GRK3 (0.45) | CYP2D6CASRADRB2ADRB3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599333-A | HYPOTENSIVE AGENTS | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1986-07-08 | — | — | US | disclosed |
| EP-0097202-A1 | Hydrazinopyridazine compound, process for production thereof, and use thereof as medicament | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1984-01-04 | — | — | EP | disclosed |