Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.48 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817414 | 0.79 | TTR (0.50) | TTRALBMEN1LMNAHTT | |
| SCHEMBL1082738 | 0.79 | TTR (0.36) | TTRACEPTGS1 | |
| SCHEMBL69776 | 0.78 | TTR (0.56) | TTRALBMEN1LMNAHTT | |
| SCHEMBL28865128 | 0.77 | TTR (0.41) | TTRALBMEN1LMNAHTT | |
| Lithium SCHEMBL30477969 | 0.77 | TTR (0.35) | TTRACEPTGS1 | |
| SCHEMBL15360551 | 0.77 | TTR (0.41) | TTRALBMEN1LMNAHTT | |
| SCHEMBL6720850 | 0.73 | TTR (0.50) | TTRALBMEN1LMNAHTT | |
| SCHEMBL19730501 | 0.73 | TTR (0.50) | TTRALBMEN1LMNAHTT | |
| SCHEMBL24110793 | 0.71 | TPMT (0.43) | TTRALBMEN1LMNAHTT | |
| SCHEMBL8410940 | 0.71 | TTR (0.48) | TTRALBMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4571435-A | SUSTAINED RELEASE | TENNESSEE VALLEY AUTHORITY (US) | 1986-02-18 | — | — | US | disclosed |
| US-4379939-A | Preparation of nitrogen fertilizers from oxalate esters prepared by the oxidative carbonylation of alcohols over noble metal catalysts utilizing regenerable 2,5-cyclohexadiene-1,4-dione oxidants | TENNESSEE VALLEY AUTHORITY (US) | 1983-04-12 | — | — | US | disclosed |