Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.60 |
| ▸ | BRD2 | P25440 | 5/20 | 0.60 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | CCKBR | P32239 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Hydroxy-Alprazolam SCHEMBL30150892 | 1.00 | BRD4 (0.60) | BRD4BRD2BRD3OPRK1LMNA | |
| 4-Hydroxy-Alprazolam SCHEMBL30150893 | 1.00 | BRD4 (0.60) | BRD4BRD2BRD3OPRK1LMNA | |
| 4-Hydroxy-Alprazolam SCHEMBL10890275 | 0.94 | BRD4 (0.60) | BRD4BRD2BRD3OPRK1LMNA | |
| SCHEMBL11390416 | 0.86 | BRD4 (0.58) | BRD4BRD2BRD3OPRK1LMNA | |
| SCHEMBL7903000 | 0.85 | BRD4 (0.62) | BRD4BRD2BRD3OPRK1LMNA | |
| SCHEMBL7895743 | 0.85 | BRD4 (0.60) | BRD4BRD2BRD3OPRK1LMNA | |
| SCHEMBL11901048 | 0.84 | BRD4 (0.77) | BRD4BRD2BRD3OPRK1LMNA | |
| SCHEMBL7903005 | 0.83 | BRD4 (0.75) | BRD4BRD2BRD3LMNASLC6A3 | |
| SCHEMBL11828757 | 0.83 | OPRK1 (0.58) | BRD4BRD2BRD3OPRK1LMNA | |
| SCHEMBL11705304 | 0.82 | BRD4 (0.61) | BRD4BRD2BRD3OPRK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4588721-A | Treatment of negative symptoms of schizophrenia | THE UPJOHN COMPANY (US) | 1986-05-13 | — | — | US | claimed |
| EP-0139460-A2 | Benzodiazepines and their therapeutic use | THE UPJOHN COMPANY (US) | 1985-05-02 | — | — | EP | claimed |
| US-4044016-A | ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3970664-A | ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE | HOFFMANN-LA ROCHE INC. (US) | 1976-07-20 | — | — | US | disclosed |
| US-3954728-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMAN-LA ROCHE INC. (US) | 1976-05-04 | — | — | US | disclosed |