Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 5/20 | 0.39 |
| ▸ | PMM2 | O15305 | 2/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730693 | 0.85 | CA2 (0.47) | MAPTTP53LMNATHRBCA2 | |
| SCHEMBL10890683 | 0.79 | MAPT (0.54) | MAPTTP53LMNATHRBCA2 | |
| SCHEMBL11408802 | 0.75 | KDM4E (0.41) | MAPTTP53LMNATHRBCA2 | |
| SCHEMBL11268696 | 0.75 | KDM4E (0.51) | MAPTTP53LMNATHRBCA2 | |
| SCHEMBL11271924 | 0.73 | TP53 (0.49) | MAPTTP53LMNATHRBCA2 | |
| SCHEMBL31158949 | 0.73 | MAPT (0.44) | MAPTTP53LMNACA2MTNR1A | |
| SCHEMBL7342130 | 0.73 | MAPT (0.44) | MAPTTP53LMNACA2MTNR1A | |
| SCHEMBL10896756 | 0.73 | CYP2A6 (0.47) | MAPTTP53LMNACA2ALDH1A1 | |
| SCHEMBL413347 | 0.71 | MAPT (0.45) | MAPTTP53LMNATHRBCA2 | |
| SCHEMBL2095397 | 0.69 | MAPT (0.44) | MAPTTP53LMNATHRBCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4614745-A | Anti-allergic 3-(carboxycarbonyl)amino benzothiopyran-4-one derivatives, compositions, and method of use therefor | CIBA-GEIGY CORPORATION (US) | 1986-09-30 | — | — | US | disclosed |
| EP-0159964-A2 | 3-Substituted thiopyrone | CIBA-GEIGY AG (CH) | 1985-10-30 | — | — | EP | disclosed |