Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | JUND | P17535 | 1/20 | 0.42 |
| ▸ | FOSB | P53539 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10637114 | 0.99 | MAPK14 (0.43) | MAPK14JUNDFOSBHTR2CTLR9 | |
| SCHEMBL11236323 | 0.81 | HTR2C (0.47) | MAPK14JUNDFOSBHTR2CDRD2 | |
| SCHEMBL10897405 | 0.81 | MAPK14 (0.47) | MAPK14JUNDFOSBHTR2CDRD2 | |
| Bromide SCHEMBL10641053 | 0.80 | MAPK14 (0.46) | MAPK14JUNDFOSBHTR2CDRD2 | |
| Hydrochloric Acid SCHEMBL29688457 | 0.80 | HTR2C (0.48) | MAPK14JUNDFOSBHTR2CDRD2 | |
| Hydrochloric Acid SCHEMBL1833385 | 0.80 | HTR2C (0.48) | MAPK14JUNDFOSBHTR2CDRD2 | |
| SCHEMBL1838388 | 0.77 | QDPR (0.48) | HTR2CDRD2HTR2A | |
| SCHEMBL23595431 | 0.76 | HTR2A (0.48) | MAPK14TLR9TLR7DRD2HTR2A | |
| SCHEMBL14034032 | 0.75 | HTR2A (0.46) | MAPK14HTR2CDRD2HTR2A | |
| SCHEMBL470707 | 0.75 | MAPK14 (0.52) | MAPK14HTR2CDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4355037-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1982-10-19 | — | — | US | claimed |
| EP-0079564-B1 | 3-(1-SUBSTITUTED-4-PIPERIDYL)-1,2-BENZISOXAZOLES, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-03-19 | — | — | EP | disclosed |
| EP-0079564-A1 | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles, a process for the preparation thereof, a pharmaceutical composition comprising the same, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-05-25 | — | — | EP | disclosed |
| US-4352811-A | NEUROLEPTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-10-05 | — | — | US | disclosed |