QDPR — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL930211	0.52	5/20
SCHEMBL2047067	0.47	5/20
SCHEMBL3390002	0.44	5/20
SCHEMBL108606	0.73	4/20
SCHEMBL1291751	0.68	4/20
SCHEMBL743362	0.50	4/20
SCHEMBL918287	0.49	4/20
SCHEMBL3361525	0.49	4/20
SCHEMBL917464	0.47	4/20
SCHEMBL3009268	0.45	4/20
SCHEMBL156312	0.44	4/20
SCHEMBL521101	0.43	4/20
SCHEMBL1856511	0.42	4/20
Hydrochloric Acid (SCHEMBL1630000)	0.41	4/20
SCHEMBL2721147	0.36	4/20
SCHEMBL3311407	0.74	3/20
SCHEMBL520554	0.68	3/20
SCHEMBL155267	0.68	3/20
SCHEMBL578138	0.68	3/20
SCHEMBL1814323	0.68	3/20

Clinical trials — most relevant to QDPR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery Disease	PHASE4	WITHDRAWN
Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study	PHASE4	UNKNOWN
A Long-Term Safety Study of PTC923 in Participants With Phenylketonuria	PHASE3	ACTIVE_NOT_RECRUITING
Efficacy and Safety Study of Azilsartan Medoxomil Compared to Ramipril for Treating Essential Hypertension	PHASE3	COMPLETED
Use of Sildenafil Citrate in Management of Mild Pre-eclampsia	PHASE2/PHASE3	UNKNOWN
Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum	PHASE3	COMPLETED
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study)	PHASE3	COMPLETED
A Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension	PHASE3	COMPLETED
A Study of PTC923 (CNSA-001) in Primary Tetrahydrobiopterin (BH4) Deficient Participants With Hyperphenylalaninemia	PHASE1/PHASE2	COMPLETED
Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease	PHASE1/PHASE2	RECRUITING
A Dose Response Study of UT-15C SR in Patients With Exercise-Induced Pulmonary Hypertension	PHASE2	COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE	PHASE2	UNKNOWN
The Effect of Antioxidants on Skin Blood Flow-BH4	PHASE1	COMPLETED
A Trial of Dextromethorphan for Treatment of Major Depressive Disorder	PHASE1	COMPLETED
Antimalarial Drug Resistance in Mali	nan	COMPLETED
Mechanistic Studies of Teriflunomide in RRMS	nan	COMPLETED
Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism	nan	COMPLETED
Pharmacogenetic Determinants Of Treatment Response In Children	nan	RECRUITING
Molecular Epidemiology of Parkinson's Disease	nan	COMPLETED
Neural Response to Catecholamine Depletion in Subjects Suffering From Bulimia Nervosa in Their Past and Healthy Controls	nan	SUSPENDED
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii	nan	ACTIVE_NOT_RECRUITING
A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care	nan	UNKNOWN
Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.	nan	COMPLETED
Study of CYP2C19 and ALDH3A1 Polymorphisms in Breast Cancer Patients	nan	UNKNOWN
Characterizing a 5P-Linked BHR Susceptibility Locus	nan	COMPLETED
Genetics and Cardiovascular Reactivity in Young Twins	nan	COMPLETED
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia	nan	RECRUITING
Genetic Determinants of Response to Beta Blockade	nan	COMPLETED
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a QDPR binder may also engage these)

Protein	Name	Similarity
Q8MJ30	—	1.000	Q8MJ30 →
Q3T0Z7	—	1.000	Q3T0Z7 →
P11348	—	0.996	P11348 →
Q8BVI4	—	0.996	Q8BVI4 →
Q8CHR6	—	0.950	Q8CHR6 →
Q2QZ86	—	0.945	Q2QZ86 →
Q28007	—	0.944	Q28007 →
A6QP05	—	0.944	A6QP05 →
Q5IH13	—	0.943	Q5IH13 →
Q6NYG8	—	0.943	Q6NYG8 →
M4IRL9	—	0.942	M4IRL9 →
BPHL	Serine hydrolase BPHL	0.942	landscape →
Q8K3F7	—	0.942	Q8K3F7 →
Q05B56	—	0.941	Q05B56 →
Q42850	—	0.941	Q42850 →
Q811X6	—	0.941	Q811X6 →
B8BJ39	—	0.941	B8BJ39 →
PPME1	Protein phosphatase methylesterase 1	0.940	landscape →
Q28943	—	0.940	Q28943 →
Q9SDT1	—	0.940	Q9SDT1 →
P15904	—	0.940	P15904 →
A7M6E8	—	0.940	A7M6E8 →
O80526	—	0.940	O80526 →
Q9CPV4	—	0.940	Q9CPV4 →
Q01289	—	0.940	Q01289 →
Q8CG45	—	0.940	Q8CG45 →
Q8MIR0	—	0.939	Q8MIR0 →
A0PJE2	—	0.939	A0PJE2 →
Q41578	—	0.939	Q41578 →
Q0VCN1	—	0.939	Q0VCN1 →