Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10899038 | 1.00 | RAB9A (0.47) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL7910349 | 0.98 | KDM4E (0.46) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL7910347 | 0.98 | KDM4E (0.46) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL7910341 | 0.98 | KDM4E (0.46) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL7902756 | 0.87 | CYP19A1 (0.47) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL7902758 | 0.87 | CYP19A1 (0.47) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL7902752 | 0.87 | CYP19A1 (0.47) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL10899373 | 0.87 | NPC1 (0.44) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL10899381 | 0.87 | NPC1 (0.44) | RAB9ANPC1CASP3ATMSENP8 | |
| SCHEMBL10901276 | 0.83 | RAB9A (0.44) | RAB9ANPC1CASP3ATMSENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4576949-A | Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein | THE UPJOHN COMPANY (US) | 1986-03-18 | — | — | US | claimed |
| EP-0161867-A2 | 5,6,7,8-Tetrahydroquinolines and 5,6-dihydropyrindines and their therapeutic use | THE UPJOHN COMPANY (US) | 1985-11-21 | — | — | EP | claimed |
| US-4576949-A | Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein | THE UPJOHN COMPANY (US) | 1986-03-18 | — | — | US | disclosed |
| EP-0161867-A2 | 5,6,7,8-Tetrahydroquinolines and 5,6-dihydropyrindines and their therapeutic use | THE UPJOHN COMPANY (US) | 1985-11-21 | — | — | EP | disclosed |