Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10902660 | 0.87 | MAPT (0.45) | ALDH1A1HTTKDM4ELMNATSHR | |
| Hydrochloric Acid SCHEMBL10904466 | 0.86 | MAPT (0.44) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL3746738 | 0.78 | PDE4A (0.46) | ALDH1A1HTTKDM4EPDE4APDE4B | |
| SCHEMBL9700828 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HTTKDM4EPDE4APDE4B | |
| SCHEMBL27450288 | 0.73 | PDE4A (0.54) | ALDH1A1KDM4EPDE4APDE4BPDE4C | |
| SCHEMBL10902263 | 0.69 | MAPT (0.47) | ALDH1A1TSHRCYP3A4RECQLCYP19A1 | |
| SCHEMBL27853895 | 0.69 | MAPT (0.48) | ALDH1A1KDM4ELMNATSHRCYP3A4 | |
| SCHEMBL715634 | 0.68 | ALDH1A1 (0.57) | ALDH1A1HTTLMNATSHRCYP3A4 | |
| SCHEMBL10904448 | 0.67 | TP53 (0.45) | ALDH1A1KDM4EPDE4APDE4BPDE4C | |
| SCHEMBL9615636 | 0.67 | KMT2A (0.48) | ALDH1A1HTTPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4602031-A | Anti-depressant imidazoles, compositions and use | EISAI CO., LTD. (JP) | 1986-07-22 | — | — | US | disclosed |
| US-4533669-A | NONTOXIC | EISAI CO., LTD. (JP) | 1985-08-06 | — | — | US | disclosed |
| US-4402966-A | Acylaminophenyl imidazoles and anti-depressing agent containing the same | EISAI CO., LTD. (JP) | 1983-09-06 | — | — | US | disclosed |
| US-4301169-A | Novel imidazole compound and anti-depressing agent containing the same | EISAI CO., LTD. (JP) | 1981-11-17 | — | — | US | disclosed |