Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 9/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.51 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21621327 | 0.92 | KMT2A (0.52) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL31620973 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL10905230 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL31620971 | 0.84 | KDM4E (0.54) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL878319 | 0.81 | GPR84 (0.50) | HSD17B10GPR84 | |
| SCHEMBL31619826 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL31620981 | 0.80 | TSHR (0.56) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL5113232 | 0.79 | TSHR (0.66) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL31619806 | 0.79 | TSHR (0.66) | KDM4EALDH1A1HPGDMAPTGLA | |
| SCHEMBL11967263 | 0.79 | TSHR (0.66) | KDM4EALDH1A1HPGDMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025124460-A1 | TRICYCLIC FUSED HETEROCYCLIC PDE3/4 DUAL INHIBITOR, AND PREPARATION AND USE THEREFOR | 石家庄以岭药业股份有限公司 | 2025-06-19 | — | — | WO | disclosed |
| CN-120136869-A | Tricyclic fused heterocyclic PDE3/4 dual inhibitor and preparation method and application thereof | 石家庄以岭药业股份有限公司 | 2025-06-13 | — | — | CN | disclosed |
| EP-0010759-B1 | PYRIMIDO (6,1-A) ISOQUINOLIN-4-ONES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION IN MEDICAMENTS; INTERMEDIATES AND THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-07-30 | — | — | EP | disclosed |
| US-4598148-A | HYPOTENSIVE AGENTS, BRONCHODIALTORS ANTIALLERGENS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-07-01 | — | — | US | disclosed |
| US-4482556-A | HYPOTENSIVE AGENTS, BRONCHODILATORS, ANTIALLERGENS | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-11-13 | — | — | US | disclosed |
| US-4400506-A | CYCLIZATION OF A BARBITURIC ACID USING AN ACID CATALYST | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-08-23 | — | — | US | disclosed |
| EP-0010759-A2 | Pyrimido (6,1-a) isoquinolin-4-ones, process for their preparation and their application in medicaments; intermediates and their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-05-14 | — | — | EP | disclosed |