SCHEMBL10907993

SCHEMBL10907993

COc1cc(Cl)c2[nH]cc(CCNC(C)=O)c2c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 20/20 0.76
MTNR1B P49286 19/20 0.76
NQO2 P16083 2/20 0.69
CYP1A2 P05177 3/20 0.63
CYP3A4 P08684 3/20 0.63
CYP2D6 P10635 3/20 0.63
MEN1 O00255 2/20 0.63
HTR2B P41595 2/20 0.63
KMT2A Q03164 2/20 0.63
KDM4E B2RXH2 2/20 0.63
HPGD P15428 2/20 0.63
HSD17B10 Q99714 2/20 0.63
ALDH1A1 P00352 1/20 0.63
CYP1A1 P04798 1/20 0.63
MPO P05164 1/20 0.63
HTR1A P08908 1/20 0.63
RAB9A P51151 1/20 0.63
BLM P54132 1/20 0.63
PMP22 Q01453 1/20 0.63
CYP1B1 Q16678 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1310442 0.86 MTNR1A (1.00) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL28811733 0.86 MTNR1A (1.00) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL10907882 0.85 MTNR1A (0.76) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL26187589 0.85 MTNR1A (0.80) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL31543641 0.84 CYP1A2 (0.61) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL15791131 0.82 MTNR1A (0.51) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL17108188 0.81 MTNR1A (1.00) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL28811319 0.81 MTNR1A (1.00) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL7893103 0.81 MTNR1A (0.69) MTNR1AMTNR1BNQO2CYP1A2CYP3A4
SCHEMBL10905707 0.78 MTNR1A (0.65) MTNR1AMTNR1BNQO2CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4614807-A ANTIFERTILITY AGENTS ELI LILLY AND COMPANY (US) 1986-09-30 US disclosed