Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.31 |
| ▸ | NMT1 | P30419 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10911568 | 0.86 | GNAO1 (0.34) | GNAO1GNAI3GNAI1NMT1 | |
| SCHEMBL10908366 | 0.84 | GBA1 (0.33) | — | |
| SCHEMBL8875557 | 0.78 | GNAO1 (0.36) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL11009735 | 0.77 | PSEN1 (0.38) | — | |
| Hydrochloric Acid SCHEMBL10910420 | 0.76 | GNAO1 (0.39) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL10911783 | 0.74 | GNAO1 (0.37) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL10910896 | 0.70 | GNAO1 (0.36) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| SCHEMBL10910844 | 0.69 | GNAO1 (0.35) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL10910999 | 0.69 | GNAO1 (0.38) | GNAO1GNAI3GNAI1ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL10912709 | 0.69 | GNAO1 (0.41) | GNAO1GNAI3GNAI1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094766-B1 | QUINAZOLINE CARDIAC STIMULANTS | Pfizer Limited (GB) | 1986-12-30 | — | — | EP | disclosed |
| US-4489075-A | Cyclic sulfonamidoalkyl substituted 4-piperidinoquinazoline cardiac stimulants | PFIZER INC. (US) | 1984-12-18 | — | — | US | disclosed |
| EP-0094766-A2 | Quinazoline cardiac stimulants | Pfizer Limited (GB) | 1983-11-23 | — | — | EP | disclosed |