GNAO1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL851007)	0.58	13/20
SCHEMBL293828	0.55	12/20
SCHEMBL465210	0.54	12/20
SCHEMBL465189	0.53	12/20
SCHEMBL1070277	0.81	11/20
SCHEMBL595977	0.92	10/20
SCHEMBL1073791	0.67	9/20
SCHEMBL162842	0.65	9/20
SCHEMBL744493	0.65	9/20
SCHEMBL744931	0.65	9/20
SCHEMBL745010	0.65	9/20
SCHEMBL44569	0.61	9/20
SCHEMBL764605	0.74	8/20
SCHEMBL768398	0.68	8/20
SCHEMBL1044731	0.68	8/20
SCHEMBL1045855	0.68	8/20
SCHEMBL754482	0.67	8/20
SCHEMBL151361	0.64	8/20
SCHEMBL249052	0.64	8/20
N-(Decanoyl)Pyrrolidine (SCHEMBL692598)	0.64	8/20

Clinical trials — most relevant to GNAO1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II	PHASE2/PHASE3	RECRUITING
Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency	PHASE3	ACTIVE_NOT_RECRUITING
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome	PHASE1/PHASE2	COMPLETED
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
First-in-Human Study With GNbAC1 in Healthy Volunteers	PHASE1	COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A	EARLY_PHASE1	COMPLETED
GNAO1 Natural History Study	nan	UNKNOWN
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia	nan	RECRUITING
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing	nan	COMPLETED
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor.	nan	UNKNOWN
GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)	nan	COMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
NGLY1 Natural History	nan	COMPLETED
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Use of miRNAs in Growth Hormone Deficiency (GHD)	nan	UNKNOWN
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)	nan	WITHDRAWN
Genomic Response Analysis of Heart Failure Therapy in African Americans	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Hepatic Substrate Flux Rates in Type 2 Diabetes	nan	ACTIVE_NOT_RECRUITING
Inherited Reproductive Disorders	nan	RECRUITING
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Investigation of Asprosin a Novel Adipokine in Periodontitis	nan	COMPLETED
A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases	nan	COMPLETED
The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population	nan	COMPLETED
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a GNAO1 binder may also engage these)

Protein	Name	Similarity
P08239	—	1.000	P08239 →
P59216	—	1.000	P59216 →
P18872	—	1.000	P18872 →
P59215	—	1.000	P59215 →
P51877	—	1.000	P51877 →
P30683	—	1.000	P30683 →
GNAI3	Guanine nucleotide-binding protein G(i) subunit alpha-3	1.000	landscape →
P38402	—	1.000	P38402 →
Q60397	—	1.000	Q60397 →
GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2	1.000	landscape →
P51876	—	1.000	P51876 →
P30682	—	1.000	P30682 →
P87032	—	1.000	P87032 →
Q9DC51	—	1.000	Q9DC51 →
P16378	—	1.000	P16378 →
GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha-1	1.000	landscape →
Q5RAD4	—	1.000	Q5RAD4 →
P08752	—	1.000	P08752 →
P51875	—	1.000	P51875 →
P38404	—	1.000	P38404 →
Q00743	—	1.000	Q00743 →
Q4R592	—	1.000	Q4R592 →
P08753	—	1.000	P08753 →
P10825	—	1.000	P10825 →
P38400	—	1.000	P38400 →
A0A436ZRX2	—	1.000	A0A436ZRX2 →
Q00580	—	1.000	Q00580 →
P50147	—	0.999	P50147 →
P30676	—	0.999	P30676 →
O13055	—	0.999	O13055 →