SCHEMBL10909263

SCHEMBL10909263

COc1cc(C)nc(NC(=O)NS(=O)(=O)c2ccccc2[N+](=O)[O-])n1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.52
MEN1 O00255 1/20 0.47
CYP2C9 P11712 1/20 0.47
KMT2A Q03164 1/20 0.47
TSHR P16473 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
POLB P06746 1/20 0.46
CDK1 P06493 1/20 0.44
THRB P10828 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
MMP1 P03956 1/20 0.43
MMP2 P08253 1/20 0.43
MMP9 P14780 1/20 0.43
MMP8 P22894 1/20 0.43
MMP13 P45452 1/20 0.43
PKM P14618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11562116 0.94 GAA (0.58) GAAKMT2ACDK1THRBL3MBTL1
SCHEMBL11112387 0.90 POLB (0.54) GAAMEN1CYP2C9KMT2ASMN1; SMN2
SCHEMBL11045802 0.90 GAA (0.48) GAAMEN1CYP2C9KMT2ATSHR
SCHEMBL10986462 0.89 POLB (0.46) GAAMEN1CYP2C9KMT2ASMN1; SMN2
SCHEMBL10454401 0.88 POLB (0.43) GAAMEN1CYP2C9KMT2ASMN1; SMN2
SCHEMBL10927440 0.88 MEN1 (0.42) GAAMEN1CYP2C9KMT2ASMN1; SMN2
SCHEMBL10647898 0.88 POLB (0.43) GAAMEN1CYP2C9KMT2ATSHR
SCHEMBL10923694 0.87 POLB (0.42) GAAMEN1CYP2C9KMT2ASMN1; SMN2
SCHEMBL8879243 0.86 GAA (0.53) GAAKMT2ACDK1THRBL3MBTL1
SCHEMBL10755571 0.86 POLB (0.44) GAAMEN1CYP2C9KMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4169719-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND CO. (US) 1979-10-02 US claimed
US-4626505-A Selectable markers for yeast transformation E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-12-02 US disclosed
EP-0154457-A1 Selectable markers for yeast transformation E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-09-11 EP disclosed
US-4453971-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-06-12 US disclosed
US-4369058-A PLANT GROWTH REGULATORS, HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1983-01-18 US disclosed
US-4225337-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-09-30 US disclosed
US-4169719-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND CO. (US) 1979-10-02 US disclosed
EP-0001515-A2 Herbicidal sulfonamides, and preparation and use thereof E.I. DU PONT DE NEMOURS AND COMPANY (US) 1979-04-18 EP disclosed