Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10908646 | 1.00 | ACE (0.62) | ACE | |
| SCHEMBL11353885 | 0.88 | ACE (0.84) | ACE | |
| SCHEMBL11045862 | 0.86 | ACE (0.64) | ACE | |
| SCHEMBL11045722 | 0.86 | ACE (0.64) | ACE | |
| SCHEMBL28974127 | 0.86 | ACE (0.59) | ACE | |
| SCHEMBL10920236 | 0.86 | — | — | |
| SCHEMBL11049197 | 0.85 | ACE (0.62) | ACE | |
| SCHEMBL27515818 | 0.84 | — | — | |
| SCHEMBL11081429 | 0.84 | — | — | |
| SCHEMBL7557379 | 0.82 | DRD4 (0.59) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024852-A1 | 2,3-Dihydro-1H-indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing these derivatives and their preparation | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-11 | — | — | EP | claimed |
| EP-0024852-B1 | 2,3-DIHYDRO-1H-INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES AND THEIR PREPARATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-09-03 | — | — | EP | disclosed |
| US-4599357-A | 1-mercaptoalkanoylindoline-2-carboxylic acids | CIBA-GEIGY CORPORATION (US) | 1986-07-08 | — | — | US | disclosed |
| US-4454291-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4454292-A | CHEMICAL INTERMEDIATES OF ANGIOTENSIN CONVERTING ENZYNE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4396773-A | 1,1'-[Dithiobis(2-alkyl-1-oxo-3,1-propanediyl)]-bis[2,3-dihydro-1H-indole-2-carboxylic acids and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-08-02 | — | — | US | disclosed |
| US-4385180-A | 10,10a-Dihydro-1H-thiozino[4,3-a,]-indole-1,4(3H)-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-05-24 | — | — | US | disclosed |
| US-4350633-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | disclosed |
| US-4303583-A | 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-12-01 | — | — | US | disclosed |
| EP-0024852-A1 | 2,3-Dihydro-1H-indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing these derivatives and their preparation | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-11 | — | — | EP | disclosed |