Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL10911789 | 0.97 | POLB (0.41) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| Diethylamine SCHEMBL10913285 | 0.94 | POLB (0.44) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| Dimethylamine SCHEMBL10909955 | 0.93 | RAB9A (0.43) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| Diethylamine SCHEMBL10911879 | 0.92 | RPS6KA2 (0.49) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| Nitric Acid SCHEMBL10909522 | 0.90 | POLB (0.43) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| Dimethylamine SCHEMBL10913831 | 0.87 | POLB (0.46) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| SCHEMBL10912915 | 0.86 | RPS6KA2 (0.47) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| Dimethylamine SCHEMBL10913852 | 0.86 | POLB (0.45) | RAB9AHPGDNPSR1RPS6KA2KMT2A | |
| Diethylamine SCHEMBL10911749 | 0.86 | RPS6KA2 (0.47) | RAB9ARPS6KA2KMT2APOLBMAPT | |
| Dimethylamine SCHEMBL10909606 | 0.85 | RPS6KA2 (0.51) | RAB9AHPGDNPSR1RPS6KA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0171977-A1 | Phthalimide derivatives, compositions containing them and a process for preparing them | SANKYO COMPANY LIMITED (JP) | 1986-02-19 | — | — | EP | claimed |
| EP-0171977-A1 | Phthalimide derivatives, compositions containing them and a process for preparing them | SANKYO COMPANY LIMITED (JP) | 1986-02-19 | — | — | EP | disclosed |