Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30444276 | 0.80 | KDM4E (0.55) | MAPTL3MBTL1TDP1HPGDCYP1A2 | |
| SCHEMBL2611837 | 0.80 | MAPT (0.57) | MAPTL3MBTL1TDP1HPGDCYP1A2 | |
| SCHEMBL25820968 | 0.80 | KDM4E (0.55) | MAPTL3MBTL1TDP1HPGDCYP1A2 | |
| SCHEMBL25551846 | 0.80 | ROS1 (0.46) | MAPTL3MBTL1TDP1HPGDCYP1A2 | |
| SCHEMBL10205892 | 0.78 | NTRK1 (0.58) | MAPTL3MBTL1TDP1HPGDCYP1A2 | |
| SCHEMBL31515064 | 0.78 | L3MBTL1 (0.51) | MAPTL3MBTL1HPGDCYP1A2CYP2C9 | |
| SCHEMBL10912479 | 0.78 | L3MBTL1 (0.51) | MAPTL3MBTL1HPGDCYP1A2CYP2C9 | |
| SCHEMBL14970168 | 0.77 | MAPT (0.54) | MAPTL3MBTL1TDP1HPGDCYP1A2 | |
| SCHEMBL27324019 | 0.77 | MAPT (0.54) | MAPTL3MBTL1TDP1HPGDCYP1A2 | |
| SCHEMBL16585346 | 0.77 | MAPT (0.54) | MAPTL3MBTL1TDP1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4598149-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-07-01 | — | — | US | disclosed |
| EP-0153746-A2 | 3-Amino-2-hydroxypropyl derivatives of pyrimidin-4-one | MERCK & CO. INC. (US) | 1985-09-04 | — | — | EP | disclosed |