SCHEMBL10911982

SCHEMBL10911982

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2-c2ccccc2)n1

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.58
CDK1 P06493 1/20 0.53
MAPT P10636 3/20 0.50
TP53 P04637 1/20 0.50
GLA P06280 1/20 0.50
EDNRA P25101 2/20 0.46
EDNRB P24530 1/20 0.46
KMT2A Q03164 1/20 0.46
CYP1A2 P05177 1/20 0.45
KDM4E B2RXH2 1/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10383478 0.93 TSHR (0.52) GAACDK1MAPTTP53GLA
SCHEMBL10616134 0.89 GAA (0.67) GAACDK1MAPTTP53GLA
SCHEMBL10568549 0.87 GAA (0.52) GAACDK1MAPTTP53GLA
SCHEMBL8162051 0.87 MAPT (0.53) GAACDK1MAPTTP53EDNRA
SCHEMBL10547831 0.86 GAA (0.51) GAACDK1MAPTTP53GLA
SCHEMBL10544656 0.85 GAA (0.50) GAACDK1MAPTTP53GLA
SCHEMBL10469643 0.85 GAA (0.59) GAACDK1MAPTTP53GLA
SCHEMBL10631446 0.84 GAA (0.54) GAACDK1MAPTTP53GLA
SCHEMBL10413453 0.84 GAA (0.54) GAACDK1MAPTTP53GLA
SCHEMBL10831453 0.84 LMNA (0.48) GAAMAPTEDNRAEDNRBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0044211-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-10-22 EP claimed
EP-0044211-A1 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1982-01-20 EP claimed
EP-0044211-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-10-22 EP disclosed
US-4378991-A Herbicidal o-aryl or alkarylsulfonylureas E. I. DU PONT DE NEMOURS AND COMPANY (US) 1983-04-05 US disclosed
EP-0044211-A1 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1982-01-20 EP disclosed