Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GLA | P06280 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606966 | 0.82 | PDE3B (0.56) | MAPTALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL10918945 | 0.81 | PDE3B (0.59) | MAPTALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL28346887 | 0.78 | GAA (0.52) | MAPTALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL27485474 | 0.77 | MAOA (0.53) | ALDH1A1PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL10918430 | 0.75 | SMN1; SMN2 (0.42) | MAPTALDH1A1SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL2729559 | 0.75 | MAPT (0.64) | MAPTALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL10532415 | 0.74 | GRIN2D (0.51) | MAPTALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL10921282 | 0.74 | PDE3B (0.58) | PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL14816279 | 0.74 | PDE3B (0.50) | ALDH1A1PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL10916724 | 0.73 | CYP11B1 (0.51) | MAPTALDH1A1PDE3BPDE3ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0093922-B1 | BENZOXAZIN-2-ONES, THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1986-12-30 | — | — | EP | disclosed |
| US-4518597-A | THROMBOSIS, ARTERIOSCLEROSIS, ANTITUMOR, ANTICOAGULANTS | DR. KARL THOMAE GMBH (DE) | 1985-05-21 | — | — | US | disclosed |
| EP-0093922-A2 | Benzoxazin-2-ones, their preparation and therapeutic agents containing these compounds | Dr. Karl Thomae GmbH (DE) | 1983-11-16 | — | — | EP | disclosed |