Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.64 |
| ▸ | F10 | P00742 | 1/20 | 0.61 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10922000 | 0.92 | PDE3B (0.56) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10463603 | 0.88 | PDE3B (0.68) | PDE3BPDE3AABCB11MAOAADORA2A | |
| Hydrochloric Acid SCHEMBL9781446 | 0.86 | PDE3B (0.66) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9781429 | 0.85 | PDE3B (0.68) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9781456 | 0.84 | PDE3B (0.77) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10771089 | 0.82 | PDE3B (0.64) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10769027 | 0.82 | PDE3B (0.64) | PDE3BPDE3AABCB11MAOAADORA2A | |
| Meribendan SCHEMBL892301 | 0.82 | PDE3B (0.70) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10769323 | 0.81 | PDE3B (0.72) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL5952845 | 0.81 | PDE3B (0.66) | PDE3BPDE3AABCB11MAOAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196005-A1 | Pyridazinones, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1986-10-01 | — | — | EP | disclosed |