Meribendan

Meribendan

SCHEMBL892301

CC1CC(=O)NN=C1c1ccc2nc(-c3cc[nH]n3)[nH]c2c1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 8/20 0.70
PDE3A Q14432 8/20 0.70
ABCB11 O95342 1/20 0.70
MAOA P21397 1/20 0.70
ADORA2A P29274 1/20 0.70
F10 P00742 1/20 0.63
PDE4A P27815 2/20 0.50
PDE4B Q07343 2/20 0.50
PDE4C Q08493 2/20 0.50
PDE4D Q08499 2/20 0.50
GPR119 Q8TDV5 10/20 0.48
GALR3 O60755 1/20 0.46
MAPT P10636 1/20 0.46
THRB P10828 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Meribendan SCHEMBL9781483 0.92 PDE3B (0.58) PDE3BPDE3AABCB11MAOAADORA2A
SCHEMBL10463603 0.83 PDE3B (0.68) PDE3BPDE3AABCB11MAOAADORA2A
SCHEMBL10769323 0.83 PDE3B (0.72) PDE3BPDE3AABCB11MAOAADORA2A
SCHEMBL5952845 0.82 PDE3B (0.66) PDE3BPDE3AABCB11MAOAADORA2A
Pimobendan SCHEMBL1649737 0.82 PDE3B (1.00) PDE3BPDE3AABCB11MAOAADORA2A
SCHEMBL9781456 0.82 PDE3B (0.77) PDE3BPDE3AABCB11MAOAADORA2A
SCHEMBL8264681 0.82 PDE3B (0.77) PDE3BPDE3AABCB11MAOAADORA2A
SCHEMBL10922011 0.82 PDE3B (0.66) PDE3BPDE3AABCB11MAOAADORA2A
SCHEMBL5951657 0.82 PDE3B (0.64) PDE3BPDE3AABCB11MAOAADORA2A
Hydrochloric Acid SCHEMBL9781446 0.82 PDE3B (0.66) PDE3BPDE3AABCB11MAOAADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
WO-2022157587-A1 A COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 WO claimed
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 US claimed
WO-2022123511-A1 A COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 WO claimed
US-20220184052-A1 COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 US claimed
US-20210393857-A1 SMALL MOLECULE DRUGS AND METHODS TO ACCELERATE OSSEOINTEGRATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-12-23 US claimed
EP-3876871-A1 SMALL MOLECULE DRUGS AND METHODS TO ACCELERATE OSSEOINTEGRATION The Regents of the University of California (US) 2021-09-15 EP claimed
US-20190046528-A1 METHOD OF PREVENTING HAIR LOSS OR PROMOTING HAIR GROWTH BY USING PHOSPHODIESTERASE 3 INHIBITOR SEOUL NATIONAL UNIVERSITY HOSPITAL (KR) 2019-02-14 US claimed
CN-101874907-B dual drug stent 科迪斯公司 2016-07-06 CN claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
EP-2246076-A2 Dual drug stent Cordis Corporation (US) 2010-11-03 EP claimed
CN-101874907-A Dual drug stent CORDIS CORP 2010-11-03 CN claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-5026705-A Benzimidazolylpyridazinones MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-06-25 US claimed
EP-0193013-B1 BENZIMIDAZOLYL-PYRIDAZINONES MERCK PATENT GmbH (DE) 1989-04-19 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210393857-A1 SMALL MOLECULE DRUGS AND METHODS TO ACCELERATE OSSEOINTEGRATION PER2, NCOR2, NR4A2 PDE3B 899/4885PDE3A 707/4885ABCB11 3748/4885
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol VNN1, LPL, HMGB1 PDE3B 837/4885PDE3A 296/4885ABCB11 2155/4885
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL VNN1, LPL, HMGB1 PDE3B 837/4885PDE3A 296/4885ABCB11 2155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.