SCHEMBL109279

SCHEMBL109279

c1cc2c(cc1CNCc1ccc3c(c1)OCO3)OCO2

nearest known ligand 0.80

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
DPP7 Q9UHL4 3/20 0.66
KDM4E B2RXH2 1/20 0.66
TSHR P16473 1/20 0.66
GAA P10253 2/20 0.66
KMT2A Q03164 3/20 0.61
MEN1 O00255 2/20 0.61
ALOX12 P18054 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
TAAR1 Q96RJ0 1/20 0.58
HPGD P15428 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL647938 0.91 ALDH1A1 (0.70) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL1042604 0.89 KMT2A (0.60) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL19392289 0.89 ALDH1A1 (0.68) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL12651867 0.89 ALDH1A1 (0.59) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL12509821 0.89 ALDH1A1 (0.63) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL1041595 0.88 ALDH1A1 (0.66) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL108732 0.87 POLB (0.69) ALDH1A1DPP7KDM4EKMT2AMEN1
SCHEMBL25990229 0.86 ALDH1A1 (0.64) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL7392627 0.86 DPP7 (0.62) ALDH1A1L3MBTL1DPP7KDM4ETSHR
SCHEMBL19326697 0.86 DPP7 (0.62) ALDH1A1L3MBTL1DPP7KDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115260148-B Compound extracted and separated from long pepper and application of compound in preparation of anti-inflammatory drugs 中南民族大学 2023-05-05 CN claimed
CN-115260148-A Compound extracted and separated from long pepper and application of compound in preparation of anti-inflammatory drugs 中南民族大学 2022-11-01 CN claimed
CN-115260148-B Compound extracted and separated from long pepper and application of compound in preparation of anti-inflammatory drugs 中南民族大学 2023-05-05 CN disclosed
CN-115260148-A Compound extracted and separated from long pepper and application of compound in preparation of anti-inflammatory drugs 中南民族大学 2022-11-01 CN disclosed
EP-3024458-A1 USE OF FLECAINIDE AS AN ANTI-CONNEXIN AGENT AND METHOD FOR POTENTIATING THE EFFECTS OF A PSYCHOTROPIC DRUG Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR) 2016-06-01 EP disclosed
US-9051253-B2 Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's PROTEOTECH INC. (US) 2015-06-09 US disclosed
US-9051253-B2 Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's PROTEOTECH INC. (US) 2015-06-09 US disclosed
WO-2015011246-A1 USE OF FLECAINIDE AS AN ANTI-CONNEXIN AGENT AND METHOD FOR POTENTIATING THE EFFECTS OF A PSYCHOTROPIC DRUG COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) 2015-01-29 WO disclosed
US-8895554-B2 Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease PROTEOTECH INC (US) 2014-11-25 US disclosed
US-8895554-B2 Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease PROTEOTECH INC (US) 2014-11-25 US disclosed
US-8754133-B2 Compounds, compositions and methods for the treatment of inflammatory diseases PROTEOTECH, INC. (US) 2014-06-17 US disclosed
US-7186734-B2 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION (US) 2007-03-06 US disclosed
EP-1490343-A1 NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS Neurogen Corporation (US) 2004-12-29 EP disclosed
EP-1480941-A2 UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS Procyon Biopharma Inc. (CA) 2004-12-01 EP disclosed
US-20040116424-A1 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION 2004-06-17 US disclosed
WO-2003082829-A1 NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS NEUROGEN CORPORATION (US) 2003-10-09 WO disclosed
WO-2003074467-A2 UREA DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS PROCYON BIOPHARMA INC. (CA) 2003-09-12 WO disclosed
US-6528532-B1 Benzenesulfonamide group PHARMACOR INC. (CA) 2003-03-04 US disclosed
US-6143917-A FROM A DIARYL CARBONATE AND AN AMINE COMPOUND HAVING AT LEAST ONE HYDROGEN ATOM LOCATED AT AN N-POSITION UNDER MODERATE CONDITIONS AT A HIGH REACTION RATE WITH A HIGH SELECTIVITY AND WITH A HIGH YIELD UBE INDUSTRIES, LTD. (JP) 2000-11-07 US disclosed
EP-0902014-A1 PROCESS FOR PRODUCING ARYL CARBAMATES UBE INDUSTRIES LIMITED (JP) 1999-03-17 EP disclosed