Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10932165 | 0.98 | HTT (0.61) | HTTTDP1SMN1; SMN2NPC1LMNA | |
| SCHEMBL10928155 | 0.84 | HTT (0.58) | HTTTDP1SMN1; SMN2NPC1LMNA | |
| SCHEMBL3369060 | 0.83 | HTT (0.76) | HTTTDP1SMN1; SMN2NPC1LMNA | |
| SCHEMBL4162497 | 0.83 | HTT (0.65) | HTTTDP1SMN1; SMN2NPC1LMNA | |
| Hydrochloric Acid SCHEMBL10998560 | 0.82 | HTT (0.56) | HTTTDP1SMN1; SMN2NPC1LMNA | |
| SCHEMBL169824 | 0.81 | TDP1 (0.76) | HTTTDP1SMN1; SMN2NPC1LMNA | |
| SCHEMBL10926979 | 0.81 | POLB (0.53) | HTTSMN1; SMN2NPC1LMNAALDH1A1 | |
| SCHEMBL7905681 | 0.80 | HTT (0.71) | HTTTDP1SMN1; SMN2NPC1LMNA | |
| SCHEMBL10930344 | 0.80 | MEN1 (0.53) | SMN1; SMN2LMNAEPHX2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL10990135 | 0.79 | POLB (0.51) | HTTSMN1; SMN2NPC1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116639-A4 | ACYL GUANIDINES. | RORER INTERNAT OVERSEAS INC (US) | 1985-09-25 | — | — | EP | claimed |
| EP-0116639-A1 | ACYL GUANIDINES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-08-29 | — | — | EP | claimed |
| WO-1984000875-A1 | ACYL GUANIDINES | RORER INT OVERSEAS (US) | 1984-03-15 | — | — | WO | claimed |
| EP-0116639-A4 | ACYL GUANIDINES. | RORER INTERNAT OVERSEAS INC (US) | 1985-09-25 | — | — | EP | disclosed |
| EP-0116639-A1 | ACYL GUANIDINES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1984-08-29 | — | — | EP | disclosed |
| WO-1984000875-A1 | ACYL GUANIDINES | RORER INT OVERSEAS (US) | 1984-03-15 | — | — | WO | disclosed |