SCHEMBL10929636

SCHEMBL10929636

NC(=O)CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 1/20 0.72
CACNA2D1 P54289 5/20 0.70
CACNB1 Q02641 5/20 0.70
CACNA1B Q00975 4/20 0.70
CACNA1C Q13936 4/20 0.70
HRH1 P35367 5/20 0.61
DRD3 P35462 3/20 0.61
KCNH2 Q12809 3/20 0.61
SLC6A2 P23975 2/20 0.61
HRH2 P25021 2/20 0.61
HTR2A P28223 2/20 0.61
SLC6A4 P31645 2/20 0.61
HTR2B P41595 2/20 0.61
SLC6A3 Q01959 2/20 0.61
USP2 O75604 2/20 0.61
TEK Q02763 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
CACNA1G O43497 2/20 0.61
CACNA1A O00555 1/20 0.60
ALOX5 P09917 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10930361 0.92 CACNA2D1 (0.65) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
SCHEMBL28935916 0.89 SLC6A9 (0.91) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
SCHEMBL4136017 0.89 SLC6A9 (0.91) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
Hydrochloric Acid SCHEMBL4140455 0.88 SLC6A9 (0.89) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
SCHEMBL14859743 0.86 SLC6A9 (0.67) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
SCHEMBL4139616 0.84 SLC6A9 (1.00) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
Hydrochloric Acid SCHEMBL4150496 0.83 SLC6A9 (0.97) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
SCHEMBL5549056 0.82 CACNA2D1 (1.00) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
SCHEMBL1376101 0.82 HRH1 (0.83) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C
SCHEMBL3847601 0.82 HRH1 (0.83) SLC6A9CACNA2D1CACNB1CACNA1BCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4525358-A ANTIHISTAMINES, ANTIALLERGENS, ANTISPASMODICS, BRONCHODILATORS UCB PHARMACEUTICALS, INC. (US) 1985-06-25 US disclosed
EP-0058146-B1 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS U C B, S.A. (BE) 1984-06-27 EP disclosed
EP-0058146-A1 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions U C B, S.A. (BE) 1982-08-18 EP disclosed