Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 7/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2058741 | 0.90 | HRH3 (0.49) | HRH3HTR7DRD2DRD4DRD3 | |
| Water SCHEMBL10930920 | 0.89 | HRH3 (0.48) | HRH3HTR7DRD2DRD4DRD3 | |
| SCHEMBL1569359 | 0.89 | HTR7 (0.50) | HRH3HTR7DRD3KDM4EALDH1A1 | |
| SCHEMBL7628259 | 0.87 | HTR7 (0.48) | HRH3HTR7DRD2DRD4DRD3 | |
| SCHEMBL11125568 | 0.87 | HTR7 (0.54) | HRH3HTR7HTR1A | |
| SCHEMBL10928076 | 0.86 | TACR1 (0.48) | HRH3HTR7DRD2TACR1HTR1A | |
| Hydrochloric Acid SCHEMBL10931643 | 0.86 | HTR7 (0.53) | HRH3HTR7HTR1A | |
| Hydrochloric Acid SCHEMBL10930120 | 0.86 | HTR7 (0.47) | HRH3HTR7DRD2DRD4DRD3 | |
| SCHEMBL7633647 | 0.85 | HTR7 (0.53) | HRH3HTR7HTR1AKDM4EALDH1A1 | |
| SCHEMBL7630560 | 0.82 | HTR7 (0.48) | HRH3HTR7DRD3TACR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525358-A | ANTIHISTAMINES, ANTIALLERGENS, ANTISPASMODICS, BRONCHODILATORS | UCB PHARMACEUTICALS, INC. (US) | 1985-06-25 | — | — | US | disclosed |
| EP-0058146-B1 | 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | U C B, S.A. (BE) | 1984-06-27 | — | — | EP | disclosed |
| EP-0058146-A1 | 2-(4-(Diphenylmethyl)-1-piperazinyl)-acetic acids and their amides, process for their preparation and pharmaceutical compositions | U C B, S.A. (BE) | 1982-08-18 | — | — | EP | disclosed |