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HTR7

5-hydroxytryptamine receptor 7 · P34969 · HTR7 on Sugi Atlas →

302,055 patent compounds predicted against HTR7, 177,110 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL111992 SCHEMBL111992 0.58 13/20
SCHEMBL113953 SCHEMBL113953 0.64 12/20
Ipsapirone Ipsapirone (SCHEMBL79574) 1.00 11/20
SCHEMBL83163 SCHEMBL83163 0.63 11/20
Azaperone Azaperone (SCHEMBL121134) 1.00 10/20
Trazodone Trazodone (SCHEMBL28167) 0.94 9/20
Trazodone Trazodone (SCHEMBL61754) 0.92 9/20
Trazodone Trazodone (SCHEMBL120883) 0.90 9/20
SCHEMBL21594 SCHEMBL21594 0.65 9/20
SCHEMBL13077 SCHEMBL13077 0.44 9/20
SCHEMBL47984 SCHEMBL47984 0.37 9/20
SCHEMBL96037 SCHEMBL96037 0.61 8/20
SCHEMBL95428 SCHEMBL95428 0.60 8/20
SCHEMBL96852 SCHEMBL96852 0.59 8/20
SCHEMBL82028 SCHEMBL82028 0.51 8/20
Penfluridol Penfluridol (SCHEMBL93939) 1.00 7/20
Oxatomide Oxatomide (SCHEMBL28824) 0.69 6/20
Pelanserin Pelanserin (SCHEMBL120877) 0.74 5/20
SCHEMBL112735 SCHEMBL112735 0.65 5/20
SCHEMBL81365 SCHEMBL81365 0.62 5/20

Clinical trials — most relevant to HTR7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder PHASE4COMPLETED
Cariprazine Versus Placebo for Social Anxiety Disorder PHASE4COMPLETED
Brexpiprazole Treatment for Bipolar I Depression PHASE3RECRUITING
Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease PHASE2COMPLETED
Testing the Ability of JNJ-18038683 to Improve Cognition and Reduce Depressive Symptoms in Stable Bipolar Patients PHASE2COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder PHASE2RECRUITING
An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression PHASE2COMPLETED
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression PHASE1/PHASE2RECRUITING
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting PHASE2COMPLETED
Lorcaserin Intra Venous Cocaine Effects PHASE1/PHASE2UNKNOWN
The Neurobiological Effect of 5-HT2AR Modulation PHASE1RECRUITING
SRC Inhibition as a Potential Target for Parkinson's Disease Psychosis EARLY_PHASE1UNKNOWN
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis nanCOMPLETED
Investigating Serotonin Signalling in IBD Patients nanRECRUITING
Imaging 5HT7 Antagonist Effects in Bipolar Disorder nanUNKNOWN
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers nanCOMPLETED
Implication of 5-HT7 Receptor in Inflammatory Mechanisms in Multiple Sclerosis nanCOMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder nanWITHDRAWN
Investigating the Neuropsychological Effects of 5-HT2a Antagonism nanRECRUITING
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health nanCOMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder nanNOT_YET_RECRUITING
PET Whole Body Distribution Studies Using [11C]CUMI nanCOMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling nanUNKNOWN
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors nanCOMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders nanCOMPLETED
Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment nanCOMPLETED
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients nanUNKNOWN
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression nanNOT_YET_RECRUITING
Vortioxetine for Cancer Patients With Depression: An Observational Study nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a HTR7 binder may also engage these)

ProteinNameSimilarity
P32305 — 0.994 P32305 →
P50407 — 0.990 P50407 →
P32304 — 0.989 P32304 →
Q91559 — 0.984 Q91559 →
O62809 — 0.972 O62809 →
Q9EQQ3 — 0.968 Q9EQQ3 →
Q9TUP7 — 0.964 Q9TUP7 →
P30731 — 0.963 P30731 →
Q9BZJ6 — 0.963 Q9BZJ6 →
P58308 — 0.963 P58308 →
Q9NYM4 — 0.963 Q9NYM4 →
HCRTR2 Orexin receptor type 2 0.961 landscape →
Q9TTQ9 — 0.960 Q9TTQ9 →
CHRM4 Muscarinic acetylcholine receptor M4 0.957 landscape →
Q8VHD7 — 0.957 Q8VHD7 →
Q8C010 — 0.957 Q8C010 →
P17200 — 0.956 P17200 →
P32211 — 0.956 P32211 →
P08485 — 0.955 P08485 →
O97661 — 0.954 O97661 →
Q8BGE9 — 0.954 Q8BGE9 →
P56719 — 0.954 P56719 →
HCRTR1 Orexin/Hypocretin receptor type 1 0.954 landscape →
Q9BZJ8 — 0.953 Q9BZJ8 →
RXFP3 Relaxin-3 receptor 1 0.953 landscape →
Q9I918 — 0.953 Q9I918 →
P47746 — 0.952 P47746 →
Q91178 — 0.952 Q91178 →
Q98895 — 0.952 Q98895 →
P20272 — 0.952 P20272 →