Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Imiloxan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.87 |
| ▸ | TSHR | P16473 | 1/20 | 0.87 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.87 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.87 |
| ▸ | MEN1 | O00255 | 1/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.85 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imiloxan SCHEMBL10934602 | 1.00 | CYP1A2 (0.87) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL757962 | 0.93 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL124122 | 0.92 | MEN1 (1.00) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL10931695 | 0.91 | TSHR (0.87) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL11010829 | 0.91 | TSHR (0.87) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL11010833 | 0.91 | TSHR (0.87) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL10931689 | 0.91 | TSHR (0.87) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL10932287 | 0.89 | CYP1A2 (0.83) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL10932290 | 0.89 | CYP1A2 (0.83) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 | |
| Imiloxan SCHEMBL10931686 | 0.88 | TSHR (0.81) | CYP1A2CYP3A4CYP2D6TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047531-B1 | 2-(1,4-BENZODIOXAN-2-YLALKYL) IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1985-06-12 | — | — | EP | disclosed |
| US-4497818-A | 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antihypertensives and platelet aggregation inhibitors | SYNTEX (U.S.A.) INC. (US) | 1985-02-05 | — | — | US | disclosed |
| EP-0047531-A1 | 2-(1,4-Benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-03-17 | — | — | EP | disclosed |