Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Methyl Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | HTT | P42858 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11381517 | 0.97 | KDM4A (0.50) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| SCHEMBL4362312 | 0.95 | KDM4A (0.49) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Methyl Alcohol SCHEMBL10934435 | 0.94 | KDM4A (0.55) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8013329 | 0.93 | KDM4A (0.48) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Bromide SCHEMBL2877131 | 0.93 | KDM4A (0.48) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Iodide SCHEMBL10938526 | 0.90 | KDM4A (0.58) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Iodide SCHEMBL10938556 | 0.90 | KDM4A (0.58) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| SCHEMBL19582692 | 0.89 | KDM4A (0.57) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| SCHEMBL19582519 | 0.89 | KDM4A (0.57) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| SCHEMBL29431056 | 0.89 | KDM4A (0.57) | KDM4AKDM2AHDAC8NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4548893-A | NEGATIVE WORKING, VINYL POLYMER HAVING AROMATIC QUATERNIZED NITROG | GTE LABORATORIES INCORPORATED (US) | 1985-10-22 | — | — | US | disclosed |