Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 10/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362312 | 0.98 | KDM4A (0.49) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8013329 | 0.97 | KDM4A (0.48) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Iodide SCHEMBL11381517 | 0.97 | KDM4A (0.50) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Methyl Alcohol SCHEMBL10936101 | 0.93 | KDM4A (0.48) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Bromide SCHEMBL28803406 | 0.93 | KDM4A (0.56) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Bromide SCHEMBL28214927 | 0.93 | KDM4A (0.56) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| Bromide SCHEMBL2425549 | 0.93 | KDM4A (0.56) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| SCHEMBL19582692 | 0.92 | KDM4A (0.57) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| SCHEMBL19582519 | 0.92 | KDM4A (0.57) | KDM4AKDM2AHDAC8NPC1RAB9A | |
| SCHEMBL29431056 | 0.92 | KDM4A (0.57) | KDM4AKDM2AHDAC8NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183016-B1 | STEREOCOMPLEX HYDROGELS | UNIV UTRECHT (NL) | 2004-04-21 | — | — | EP | claimed |
| US-20100255098-A1 | STEREOCOMPLEX HYDROGELS | UNIVERSITEIT UTRECHT (NL) | 2010-10-07 | — | — | US | disclosed |
| US-7776359-B1 | Stereocomplex hydrogels | UNIVERSITEIT UTRECHT (NL) | 2010-08-17 | — | — | US | disclosed |
| EP-1183016-B1 | STEREOCOMPLEX HYDROGELS | UNIV UTRECHT (NL) | 2004-04-21 | — | — | EP | disclosed |
| US-6684683-B2 | Method and apparatus for characterizing the barrier properties of members of combinatorial libraries | GENERAL ELECTRIC COMPANY | 2004-02-03 | — | — | US | disclosed |
| US-20030160194-A1 | Method and apparatus for characterizing the barrier properties of members of combinatorial libraries | GENERAL ELECTRIC COMPANY | 2003-08-28 | — | — | US | disclosed |
| US-5667895-A | HYDROPHILIC POLYMER AND COMPATABLE LIQUID IN A VISCOUS COLLOID, FOOTWEAR | JENKNER BRIAN D (US) | 1997-09-16 | — | — | US | disclosed |
| US-5529877-A | Microcapsule toner and processes for preparation of microcapsule and microcapsule toner | FUJI XEROX CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| US-5385802-A | Process for producing toner | FUJI XEROX CO., LTD. (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0610217-A4 | IMPROVEMENTS IN PAPER MAKING. | DELTA CHEMICALS INC (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5336582-A | Electrophotographic image formation comprising an arylamine in a charge transport layer and an encapsulated toner | FUJI XEROX CO., LTD. (JP) | 1994-08-09 | — | — | US | disclosed |
| WO-1993025754-A1 | IMPROVEMENTS IN PAPER MAKING | DELTA CHEMICALS, INC. (US) | 1993-12-23 | — | — | WO | disclosed |
| US-5178730-A | Medium/high molecular weight cationic polymers and hectorite for paper | DELTA CHEMICALS (US) | 1993-01-12 | — | — | US | disclosed |
| US-4927447-A | HYDRATION, DEHYDRATION OF HYDROPHILIC POLYMER | YOUSSEF NABIL N (US) | 1990-05-22 | — | — | US | disclosed |
| US-4762545-A | FERTILIZERS, NUTRIENTS, WATER SWELLING POLYMERS | YOUSSEF NABIL N (US) | 1988-08-09 | — | — | US | disclosed |
| US-4655076-A | Moisture measuring apparatus | RAYCHEM CORPORATION (US) | 1987-04-07 | — | — | US | disclosed |
| US-4548893-A | NEGATIVE WORKING, VINYL POLYMER HAVING AROMATIC QUATERNIZED NITROG | GTE LABORATORIES INCORPORATED (US) | 1985-10-22 | — | — | US | disclosed |
| US-4456678-A | High resolution lithographic resist of negative working cationic vinyl polymer | GTE LABORATORIES INCORPORATED (US) | 1984-06-26 | — | — | US | disclosed |
| US-4269188-A | MULTILAYER, ABSORBENT POLYMER POWDER, FLUFF PULP, HIGH AND LOW WET STRENGTH PAPER | KAO SOAP CO., LTD. (JP) | 1981-05-26 | — | — | US | disclosed |
| US-4058124-A | Disposable absorbent articles containing particulate, free-flowing, insoluble swellable polymers | UNION CARBIDE CORPORATION (US) | 1977-11-15 | — | — | US | disclosed |