Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.56 |
| ▸ | FFAR2 | O15552 | 9/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940835 | 0.89 | ACE (0.60) | ACEFFAR2HTTPOLBALDH1A1 | |
| SCHEMBL11065988 | 0.85 | ACE (0.67) | ACELMNA | |
| SCHEMBL683556 | 0.85 | ACE (0.67) | ACELMNA | |
| SCHEMBL11194036 | 0.84 | ACE (0.59) | ACEFFAR2HTTPOLBALDH1A1 | |
| SCHEMBL683644 | 0.83 | ACE (0.67) | ACEFFAR2HTTPOLBALDH1A1 | |
| SCHEMBL11062257 | 0.80 | ACE (0.55) | ACEFFAR2HTTLMNA | |
| SCHEMBL683927 | 0.80 | ACE (0.52) | ACEPOLBALDH1A1 | |
| SCHEMBL10968292 | 0.77 | ACE (0.64) | ACEFFAR2HTTPOLBALDH1A1 | |
| SCHEMBL11075090 | 0.76 | FFAR2 (0.52) | ACEFFAR2HTT | |
| SCHEMBL11062261 | 0.75 | ACE (0.56) | ACEFFAR2HTTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |