SCHEMBL10941016

SCHEMBL10941016

Cc1c(Cl)c(C)c([N+](=O)[O-])c(C(C)(C)C)c1[N+](=O)[O-]

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.39
ALDH1A1 P00352 6/20 0.38
TDP1 Q9NUW8 3/20 0.38
GRIN2D O15399 2/20 0.33
GRIN3B O60391 2/20 0.33
GRIN1 Q05586 2/20 0.33
GRIN2A Q12879 2/20 0.33
GRIN2B Q13224 2/20 0.33
GRIN2C Q14957 2/20 0.33
GRIN3A Q8TCU5 2/20 0.33
NPC1 O15118 1/20 0.30
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
XBP1 P17861 1/20 0.30
RAB9A P51151 1/20 0.30
PAX8 Q06710 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
TLR9 Q9NR96 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL273394 0.85 TSHR (0.41) TSHRALDH1A1TDP1GRIN2DGRIN3B
SCHEMBL1224154 0.85 TSHR (0.41) TSHRALDH1A1TDP1GRIN2DGRIN3B
SCHEMBL4928732 0.83 TDP1 (0.40) TSHRALDH1A1TDP1GRIN2DGRIN3B
SCHEMBL4928738 0.83 TDP1 (0.40) TSHRALDH1A1TDP1GRIN2DGRIN3B
SCHEMBL4923849 0.79 ALDH1A1 (0.39) TSHRALDH1A1TDP1MAPTSMN1; SMN2
SCHEMBL27322672 0.79 MEN1 (0.41) TSHRALDH1A1TDP1GRIN2DGRIN3B
SCHEMBL2182723 0.77 ALDH1A1 (0.37) TSHRALDH1A1TDP1MAPTSMN1; SMN2
SCHEMBL10595994 0.77 TSHR (0.48) TSHRALDH1A1TDP1GRIN2DGRIN3B
SCHEMBL18770245 0.76 ALDH1A1 (0.36) TSHRALDH1A1TDP1GRIN2DGRIN3B
SCHEMBL27707209 0.75 TSHR (0.46) TSHRALDH1A1TDP1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0047317-B1 HALOGEN CONTAINING CYCLOHEXANE DERIVATIVES, METHODS OF PREPARATION AND COMPOSITIONS CONTAINING SAME FRITZSCHE DODGE & OLCOTT INC. (US) 1985-01-23 EP disclosed
EP-0047317-A4 HALOGEN CONTAINING CYCLOHEXANE DERIVATIVES, METHODS OF PREPARATION AND COMPOSITIONS CONTAINING SAME. FRITZSCHE DODGE & OLCOTT INC (US) 1982-07-13 EP disclosed
EP-0047317-A1 HALOGEN CONTAINING CYCLOHEXANE DERIVATIVES, METHODS OF PREPARATION AND COMPOSITIONS CONTAINING SAME. FRITZSCHE DODGE & OLCOTT INC (US) 1982-03-17 EP disclosed
US-4308401-A CHLORINATION OR BROMINATION WITH HYPOHALOUS ACID FRITZSCHE DODGE & OLCOTT INC. (US) 1981-12-29 US disclosed
WO-1981002518-A1 HALOGEN CONTAINING CYCLOHEXANE DERIVATIVES,METHODS OF PREPARATION AND COMPOSITIONS CONTAINING SAME FRITZSCHE DODGE & OLCOTT INC (US) 1981-09-17 WO disclosed
US-4272412-A FRAGRANCES FRITZSCHE DODGE & OLCOTT INC. (US) 1981-06-09 US disclosed