Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10940664 | 0.84 | ACE (0.75) | ACELMNAALDH1A1FFAR2POLB | |
| SCHEMBL10944736 | 0.81 | ACE (0.58) | ACELMNAALDH1A1FFAR2POLB | |
| SCHEMBL10942643 | 0.81 | POLB (0.43) | ACEALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL11000518 | 0.81 | POLB (0.43) | ACEALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL10941388 | 0.81 | POLB (0.43) | ACEALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL10941007 | 0.80 | ACE (0.77) | ACELMNAALDH1A1FFAR2POLB | |
| SCHEMBL11004289 | 0.80 | ACE (0.80) | ACELMNAALDH1A1FFAR2POLB | |
| SCHEMBL10944246 | 0.80 | L3MBTL1 (0.44) | ACEALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL10942993 | 0.80 | L3MBTL1 (0.44) | ACEALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL10944250 | 0.78 | ACE (0.53) | ACELMNAALDH1A1FFAR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |