Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095191 | 0.89 | SCN9A (0.59) | SCN9ACYP3A4CYP2C9SCN2ASCN8A | |
| SCHEMBL1094268 | 0.81 | SCN9A (0.50) | SCN9ACYP3A4CYP2C9 | |
| SCHEMBL1094346 | 0.76 | SCN9A (0.59) | SCN9ACYP3A4CYP2C9SCN2ASCN8A | |
| SCHEMBL1093796 | 0.76 | SCN9A (0.61) | SCN9ACYP3A4CYP2C9SCN2ASCN8A | |
| SCHEMBL1094338 | 0.69 | PIK3CD (0.38) | SCN9A | |
| SCHEMBL16531559 | 0.69 | SCN9A (1.00) | SCN9ACYP3A4CYP2C9SCN2ASCN8A | |
| SCHEMBL1095194 | 0.67 | SCN9A (0.57) | SCN9ACYP3A4CYP2C9SCN2ASCN8A | |
| SCHEMBL16531628 | 0.66 | SCN9A (1.00) | SCN9ACYP3A4CYP2C9SCN2ASCN8A | |
| Pf-05150122 SCHEMBL1094447 | 0.65 | SCN9A (1.00) | SCN9ACYP3A4CYP2C9SCN2ASCN8A | |
| SCHEMBL1094823 | 0.64 | IDO1 (0.38) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |