Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.34 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094850 | 0.77 | PIK3CD (0.33) | PIK3CDPIK3CAABCC9ABCC8KCNJ11 | |
| SCHEMBL326998 | 0.74 | PIK3CD (0.33) | PIK3CDPIK3CASGK1PIK3CBPIK3CG | |
| SCHEMBL15867026 | 0.68 | ACLY (0.49) | PIK3CDPIK3CAPTGDR2HSP90AA1HSP90AB1 | |
| SCHEMBL28335542 | 0.64 | PIK3CD (0.45) | PIK3CDPIK3CAPTGDR2HSP90AA1HSP90AB1 | |
| SCHEMBL20766835 | 0.64 | ACLY (0.50) | PTGDR2HSP90AA1HSP90AB1ACLYSGK1 | |
| SCHEMBL1094341 | 0.64 | PTGDR2 (0.35) | PIK3CDPIK3CAPTGDR2HSP90AA1HSP90AB1 | |
| SCHEMBL4900667 | 0.63 | GRM4 (0.59) | ABCC9ABCC8KCNJ11KCNJ8GRM4 | |
| SCHEMBL3363359 | 0.63 | RORC (0.45) | HSP90AA1HSP90AB1ACLYSGK1RORC | |
| SCHEMBL12327372 | 0.63 | EPAS1 (0.55) | PTGDR2HSP90AA1HSP90AB1ACLY | |
| SCHEMBL15358865 | 0.62 | ACLY (0.56) | HSP90AA1HSP90AB1ACLYSGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |