Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL967556 | 0.94 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL22500791 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL7043290 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL4606121 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL9194626 | 0.88 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL16196748 | 0.85 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL323849 | 0.83 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL28142950 | 0.83 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2MAPTSLC22A2SLC22A1 | |
| Biphenyl SCHEMBL15347228 | 0.81 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT | |
| Biphenyl SCHEMBL5868585 | 0.81 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HPGDL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101167-B1 | PROCESS FOR HYDROXYLATING OLEFINS IN THE PRESENCE OF AN OSMIUM CONTAINING CATALYST AND ORGANIC HALOGENATED HYDROCARBON CO-CATALYST | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |
| EP-0053023-B1 | HYDROXYLATION OF OLEFINS | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1985-04-17 | — | — | EP | disclosed |
| US-4482763-A | Process for hydroxylating olefins in the presence of an osmium containing catalyst and organic halogenated hydrocarbon co-catalyst | EXXON RESEARCH & ENGINEERING CO. (US) | 1984-11-13 | — | — | US | disclosed |
| EP-0101167-A1 | Process for hydroxylating olefins in the presence of an osmium containing catalyst and organic halogenated hydrocarbon co-catalyst | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1984-02-22 | — | — | EP | disclosed |
| US-4393253-A | Hydroxylation of olefins | EXXON RESEARCH & ENGINEERING CO. (US) | 1983-07-12 | — | — | US | disclosed |