Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.49 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.49 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.49 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.49 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | NSD2 | O96028 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CASP7 | P55210 | 2/20 | 0.58 |
| ▸ | CASP6 | P55212 | 2/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 10/20 | 0.49 |
| ▸ | MAOB | P27338 | 10/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10947158 | 1.00 | KDM4E (0.65) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10947418 | 1.00 | KDM4E (0.65) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10947421 | 1.00 | KDM4E (0.65) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10949538 | 0.97 | KDM4E (0.67) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10949543 | 0.97 | KDM4E (0.67) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10945302 | 0.95 | KDM4E (0.67) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10945295 | 0.95 | KDM4E (0.67) | KDM4ENSD2MAPTCASP7CASP6 | |
| SCHEMBL10949657 | 0.92 | KDM4E (0.64) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10944439 | 0.92 | KDM4E (0.69) | KDM4ENSD2MAPTCASP7CASP6 | |
| Fumaric Acid SCHEMBL10944427 | 0.92 | KDM4E (0.69) | KDM4ENSD2MAPTCASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4554279-A | PLASMODICIDAL | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1985-11-19 | — | — | US | disclosed |