Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.56 |
| ▸ | MME | P08473 | 2/20 | 0.52 |
| ▸ | REN | P00797 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10947100 | 0.89 | MME (0.65) | ACEMMELTA4H | |
| SCHEMBL10944111 | 0.88 | POLB (0.48) | ACERENSMN1; SMN2LMNAABCB11 | |
| SCHEMBL11008763 | 0.86 | MME (0.68) | ACEMMESMN1; SMN2LMNAABCB11 | |
| SCHEMBL13892769 | 0.86 | ACE (0.50) | ACERENSMN1; SMN2LMNAABCB11 | |
| SCHEMBL4669890 | 0.85 | ACE (0.60) | ACERENSMN1; SMN2LMNAABCB11 | |
| SCHEMBL4669921 | 0.85 | ACE (0.60) | ACERENSMN1; SMN2LMNAABCB11 | |
| SCHEMBL1221172 | 0.85 | ACE (0.60) | ACERENSMN1; SMN2LMNAABCB11 | |
| SCHEMBL3369452 | 0.85 | ACE (0.60) | ACERENSMN1; SMN2LMNAABCB11 | |
| SCHEMBL3780597 | 0.85 | ACE (0.60) | ACERENSMN1; SMN2LMNAABCB11 | |
| SCHEMBL497515 | 0.85 | ACE (0.60) | ACERENSMN1; SMN2LMNAABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054862-B1 | SUBSTITUTED DIPEPTIDES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE INHIBITION OF ENKEPHALINASE | SCHERING CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |
| EP-0054862-A1 | Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase | SCHERING CORPORATION (US) | 1982-06-30 | — | — | EP | disclosed |