Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 2/20 | 0.49 |
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10919018 | 0.98 | PIM3 (0.47) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL6363938 | 0.83 | KDM4E (0.44) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL4166587 | 0.81 | KDM4E (0.46) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| Hydrochloric Acid SCHEMBL28348295 | 0.79 | KDM4E (0.44) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL11272207 | 0.79 | KDM4E (0.45) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL10961400 | 0.79 | KDM4E (0.49) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL10915710 | 0.79 | KDM4E (0.41) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL31735543 | 0.78 | SMN1; SMN2 (0.37) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL15230652 | 0.78 | SMN1; SMN2 (0.48) | PIM3CDK8ACVR1DAPK3PRKD3 | |
| SCHEMBL9410482 | 0.78 | KDM4E (0.66) | PIM3CDK8ACVR1DAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020263935-A1 | HCK DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| EP-2499143-B1 | N7-SUBSTITUTED PURINE AND PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-03-16 | — | — | EP | disclosed |
| US-8828990-B2 | N-7 substituted purine and pyrazolopyrimine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-8828990-B2 | N-7 substituted purine and pyrazolopyrimine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-8828990-B2 | N-7 substituted purine and pyrazolopyrimine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| EP-1400522-B1 | COMPOUNDS FOR TREATING IMPOTENCE | GUANGZHOU YOUCARE BIOPHARMACEATICS CO LTD (CN) | 2014-08-06 | — | — | EP | disclosed |
| CN-102712642-A | N-7 substituted purine and pyrazolopyrimidine compounds, compositions and methods of use | HOFFMANN LA ROCHE | 2012-10-03 | — | — | CN | disclosed |
| EP-2499143-A1 | N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058025-A1 | N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011058025-A1 | N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |
| US-4663326-A | CARDIOTONIC, BRONCHODILATION | WARNER-LAMBERT COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| EP-0095289-B1 | IMIDAZO(1,2-C)PYRAZOLO(3,4-E)PYRIMIDINES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0201188-A2 | 5-Substituted pyrazolo[4,3-d] pyrimidine-7-ones, process for preparing the compounds and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1986-12-17 | — | — | EP | disclosed |
| EP-0023707-B1 | SUBSTITUTED TETRAAZATRICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1986-04-30 | — | — | EP | disclosed |
| US-4469868-A | ANTIPSYCHOTIC ANGENTS | WARNER-LAMBERT COMPANY (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0095289-A2 | Imidazo(1,2-c)pyrazolo(3,4-e)pyrimidines and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |
| EP-0064775-A1 | Substituted tetraazatricyclic compounds, process for their preparation and their use | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-11-17 | — | — | EP | disclosed |
| US-4317823-A | FOR TREATMENT OF GASTROINTESTINAL DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-03-02 | — | — | US | disclosed |
| EP-0023707-A1 | Substituted tetraazatricyclic compounds, process for their preparation, their use and medicines containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |
| US-3939161-A | ANTIINFLAMMATORY, ANTISECRETORY | ABBOTT LABORATORIES (US) | 1976-02-17 | — | — | US | disclosed |