Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentopril SCHEMBL1133661 | 1.00 | ACE (0.67) | ACE | |
| Pentopril SCHEMBL109521 | 1.00 | ACE (0.67) | ACE | |
| Pentopril SCHEMBL7266503 | 1.00 | ACE (0.67) | ACE | |
| Pentopril SCHEMBL7266499 | 1.00 | ACE (0.67) | ACE | |
| SCHEMBL10817709 | 0.94 | ACE (0.62) | ACE | |
| SCHEMBL10815130 | 0.91 | ACE (0.55) | ACE | |
| SCHEMBL10810410 | 0.89 | ACE (0.66) | ACE | |
| SCHEMBL10815762 | 0.89 | ACE (0.59) | ACE | |
| SCHEMBL828672 | 0.87 | ACE (0.75) | ACE | |
| SCHEMBL11196761 | 0.87 | ACE (0.75) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4950 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4710928-A2 | METHODS OF TREATING IGA NEPHROPATHY WITH ATRASENTAN | Chinook Therapeutics, Inc. (US) | 2026-03-18 | — | — | EP | claimed |
| EP-4076652-B1 | A PHARMACEUTICALLY ACCEPTABLE SALT OF ATRASENTAN FOR USE IN A METHOD OF TREATING IGA NEPHROPATHY | CHINOOK THERAPEUTICS INC (US) | 2025-12-03 | — | — | EP | claimed |
| US-20250352511-A1 | METHODS OF TREATING FOCAL SEGMENTAL GLOMERULOSCLEROSIS WITH ATRASENTAN | CHINOOK THERAPEUTICS INC (US) | 2025-11-20 | — | — | US | claimed |
| EP-4525857-A1 | METHODS OF TREATING FOCAL SEGMENTAL GLOMERULOSCLEROSIS WITH ATRASENTAN | Chinook Therapeutics, Inc. (US) | 2025-03-26 | — | — | EP | claimed |
| US-12121509-B2 | Methods of improving renal function | CHINOOK THERAPEUTICS, INC. (US) | 2024-10-22 | — | — | US | claimed |
| WO-2023225163-A1 | METHODS OF TREATING FOCAL SEGMENTAL GLOMERULOSCLEROSIS WITH ATRASENTAN | CHINOOK THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | WO | claimed |
| US-20230364055-A1 | METHODS OF IMPROVING RENAL FUNCTION | CHINOOK THERAPEUTICS, INC. | 2023-11-16 | — | — | US | claimed |
| US-20230270718-A1 | METHODS OF TREATING DIABETIC KIDNEY DISEASE | CHINOOK THERAPEUTICS INC (US) | 2023-08-31 | — | — | US | claimed |
| CN-115768421-A | Method for treating diabetic nephropathy | 切诺克治疗公司 | 2023-03-07 | — | — | CN | claimed |
| EP-4132509-A2 | METHODS OF TREATING DIABETIC KIDNEY DISEASE | Chinook Therapeutics, Inc. (US) | 2023-02-15 | — | — | EP | claimed |
| EP-0273696-A2 | Renin inhibitors containing histidine replacements | MERCK & CO. INC. (US) | 1988-07-06 | — | — | EP | claimed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | claimed |
| EP-0220107-A2 | Use of angiotensin-converting enzyme inhibitors in macular degeneration | MERCK & CO. INC. (US) | 1987-04-29 | — | — | EP | claimed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0163237-A2 | Di- and tri-peptidal renin inhibitors | MERCK & CO. INC. (US) | 1985-12-04 | — | — | EP | claimed |
| EP-0157409-A2 | Renin inhibitors containing 2-substituted statine | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | claimed |
| EP-0156318-A2 | C-terminal amide cyclic renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0156322-A2 | Renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0129189-A2 | Renin inhibitors containing a C-terminal amide cycle and compositions and combinations containing the same | MERCK & CO. INC. (US) | 1984-12-27 | — | — | EP | claimed |
| US-4374847-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-02-22 | — | — | US | claimed |