Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11196761 | 1.00 | ACE (0.75) | ACE | |
| Water SCHEMBL11075523 | 0.99 | ACE (0.73) | ACE | |
| SCHEMBL11171425 | 0.88 | ACE (0.76) | ACE | |
| Pentopril SCHEMBL109520 | 0.87 | ACE (0.67) | ACE | |
| Pentopril SCHEMBL1133661 | 0.87 | ACE (0.67) | ACE | |
| Pentopril SCHEMBL7266503 | 0.87 | ACE (0.67) | ACE | |
| Pentopril SCHEMBL109521 | 0.87 | ACE (0.67) | ACE | |
| Pentopril SCHEMBL7266499 | 0.87 | ACE (0.67) | ACE | |
| SCHEMBL10813979 | 0.86 | ACE (0.57) | ACE | |
| SCHEMBL10811917 | 0.86 | ACE (0.66) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662987-B2 | Oxidation of 1-acyl alkyl compound under anhydrous condition | XENOPORT, INC. (US) | 2010-02-16 | — | — | US | claimed |
| US-20080255073-A1 | COMPOUNDS FOR SUSTAINED RELEASE OF ORALLY DELIVERED DRUGS | XONOPORT, INC. (US) | 2008-10-16 | — | — | US | claimed |
| US-4374847-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-02-22 | — | — | US | claimed |
| US-8642644-B2 | Ophthamological drugs | DUKE UNIVERSITY (US) | 2014-02-04 | — | — | US | disclosed |
| US-20130017248-A1 | Cationic Liposomes And Method of Use | Life Technologies Corporation (US) | 2013-01-17 | — | — | US | disclosed |
| US-8143437-B2 | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof | XENOPORT, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8017776-B2 | Methods for synthesis of acyloxyalkyl compounds | XENOPORT, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-7919454-B2 | Methods of treating using conjugates transported by a PEPT2 transporter | XENOPORT, INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7825238-B2 | Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine | MEDIVIR AB (SE) | 2010-11-02 | — | — | US | disclosed |
| US-20100228015-A1 | PRODRUG DERIVATIVES OF ACIDS USING ALCOHOLS WITH HOMOTOPIC HYDROXY GROUPS AND METHODS FOR THEIR PREPARATION AND USE | DELONG MITCHELL A | 2010-09-09 | — | — | US | disclosed |
| US-7727976-B2 | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs | XENOPORT, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-5660851-A | COVALENT ATTACHMENTOF A CARBOXYLIC ACID-CONTAINING ACTIVE MATERIAL THROUGH ANHYDRIDE BONDS TO A POLYMER THAT CONTAINS PENDANT CARBOXYLIC ACID GROUPS; DRUG DELIVERY | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIV. OF JERUSALEM (IL) | 1997-08-26 | — | — | US | disclosed |
| US-5073641-A | PRODRUG DERIVATIVES OF CARBOXYLIC ACID DRUGS | BUNDGAARD HANS (DK) | 1991-12-17 | — | — | US | disclosed |
| EP-0278977-A1 | PRODRUG DERIVATIVES OF CARBOXYLIC ACID DRUGS. | BUNDGAARD HANS (DK) | 1988-08-24 | — | — | EP | disclosed |
| WO-1988001615-A1 | PRODRUG DERIVATIVES OF CARBOXYLIC ACID DRUGS | BUNDGAARD HANS (DK) | 1988-03-10 | — | — | WO | disclosed |
| EP-0105919-B1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES | CIBA-GEIGY AG (CH) | 1987-07-08 | — | — | EP | disclosed |
| US-4479963-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-10-30 | — | — | US | disclosed |
| EP-0105919-A1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES. | CIBA GEIGY AG (CH) | 1984-04-25 | — | — | EP | disclosed |
| WO-1983003828-A1 | 1-CARBOXYALKANOYLPERHYDROINDOLE-2-CARBOXYLIC ACIDS AND DERIVATIVES | CIBA-GEIGY AG (CH) | 1983-11-10 | — | — | WO | disclosed |
| US-4374847-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255073-A1 | COMPOUNDS FOR SUSTAINED RELEASE OF ORALLY DELIVERED DRUGS | ABCB11, ABCB1, SLC10A1 | ACE 1044/4885 |
| US-20100228015-A1 | PRODRUG DERIVATIVES OF ACIDS USING ALCOHOLS WITH HOMOTOPIC HYDROXY GROUPS AND METHODS FOR THEIR PREPARATION AND USE | HCAR1, HCAR2, PAICS | ACE 1148/4885 |
| US-20130017248-A1 | Cationic Liposomes And Method of Use | CLTB, AGBL2, CLTC | ACE 4724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.