Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1324146 | 0.84 | CA12 (0.53) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL30701731 | 0.84 | CA12 (0.53) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL2811677 | 0.83 | KDM4E (0.49) | NR4A2CHEK1METGSK3BLIMK1 | |
| Hydrochloric Acid SCHEMBL30701699 | 0.83 | CA12 (0.51) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL497960 | 0.83 | NR4A2 (0.49) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL10953551 | 0.82 | CHEK1 (0.43) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL6130768 | 0.81 | TBXAS1 (0.50) | MAPTKMT2AHSD17B10ALDH1A1RECQL | |
| SCHEMBL4058371 | 0.80 | MAPT (0.49) | NR4A2CYP46A1MAPTTDP1KMT2A | |
| SCHEMBL17122504 | 0.79 | CFTR (0.55) | CHEK1METGSK3BLIMK1DYRK1A | |
| SCHEMBL2811662 | 0.79 | CA12 (0.44) | NR4A2CHEK1METGSK3BLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4551468-A | INDOLE, BENZOFURANS, BENZOTHIOPHENES | PFIZER INC. (US) | 1985-11-05 | — | — | US | disclosed |
| EP-0050957-B1 | HETEROCYCLIC THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1984-08-22 | — | — | EP | disclosed |
| US-4410539-A | Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them | PFIZER INC. (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0050957-A1 | Heterocyclic thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1982-05-05 | — | — | EP | disclosed |