Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrazinecarboxamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazinecarboxamide SCHEMBL31298907 | 0.94 | TSHR (0.62) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Hydrazinecarboxamide SCHEMBL159341 | 0.94 | — | — | |
| Hydrazinecarboxamide SCHEMBL28223066 | 0.92 | TSHR (0.59) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Hydrazinecarboxamide SCHEMBL9860770 | 0.92 | TSHR (0.59) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Hydrazinecarboxamide SCHEMBL9859973 | 0.92 | TSHR (0.59) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Hydrazinecarboxamide SCHEMBL10948322 | 0.84 | TSHR (0.50) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Hydrazinecarboxamide SCHEMBL10947599 | 0.84 | TSHR (0.50) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Urea SCHEMBL10953562 | 0.82 | CA5A (0.57) | TSHRLMNACA5ACA5BCYP3A4 | |
| Nitric Acid SCHEMBL1173278 | 0.79 | CA5A (0.53) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Nitric Acid SCHEMBL27487949 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4531962-A | High-analysis in situ partially ammoniated liquid fertilizer solution which is reaction product of urea, phosphoric acid, commercial nitrogen solution | TENNESSEE VALLEY AUTHORITY (US) | 1985-07-30 | — | — | US | claimed |