CA5A

Carbonic anhydrase 5A, mitochondrial · P35218 · CA5A on Sugi Atlas →

230,277 patent compounds predicted against CA5A, 147,153 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL19880	0.55	9/20
Mafenide (SCHEMBL41627)	0.77	8/20
SCHEMBL35394	0.48	8/20
Topiramate (SCHEMBL34631)	1.00	7/20
SCHEMBL8588	0.43	7/20
Coumarin (SCHEMBL6252)	1.00	6/20
SCHEMBL34781	0.51	6/20
SCHEMBL16810	0.42	6/20
Benzthiazide (SCHEMBL26257)	0.39	6/20
Benzenesulfonamide (SCHEMBL729)	1.00	5/20
Sulfanilamide (SCHEMBL740)	1.00	5/20
Mafenide (SCHEMBL41628)	1.00	5/20
SCHEMBL3604	0.53	5/20
SCHEMBL26058	0.53	5/20
Spermine (SCHEMBL14965)	1.00	4/20
Trientine (SCHEMBL15439)	1.00	4/20
Spermidine (SCHEMBL15618)	1.00	4/20
SCHEMBL15797	1.00	4/20
Acetazolamide (SCHEMBL23219)	1.00	4/20
SCHEMBL26707	1.00	4/20

Clinical trials — most relevant to CA5A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Dexmedetomidine Effect on Mitochondrial Function	PHASE4	UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
DHA For The Treatment of Pediatric Concussion Related to Sports Injury	PHASE1	COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours	PHASE1	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Human Adaptation to High Altitude	nan	UNKNOWN
The Crosstalk Between the Epigenome and Mitochondria in SCI	nan	NOT_YET_RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
TBI Multimodal Monitoring Study	nan	UNKNOWN
Risk Factors Associated With High Altitude Sickness: A Case-Control Study	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Saturated Fat Versus Monounsaturated Fat and Insulin Action	nan	COMPLETED
Combined Intracerebral and Jugular Bulb Microdialysis	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Mitochondrial Function in the Peri-operative Setting: an Observational Study	nan	NOT_YET_RECRUITING
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Angiogenesis Induced in the Elderly by Hyperbaric Oxygen Therapy	nan	COMPLETED
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder	nan	COMPLETED
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure	nan	RECRUITING
Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort	nan	COMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
REFUEL PCOS Study 1	nan	UNKNOWN
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Expression of Markers Related to Mitochondrial Functionality in Carcinoma of the Urinary Bladder: Comparative Retrospective Analysis Between Recurrent Tumors (Non-responders) and Non-recurrent Tumors (Responders) After Intravesical Treatment With Chemotherapy or Immunotherapy	nan	UNKNOWN
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CA5A binder may also engage these)

Protein	Name	Similarity
P23589	—	0.981	P23589 →
Q9QZA0	—	0.981	Q9QZA0 →
Q66HG6	—	0.980	Q66HG6 →
CA5B	Carbonic anhydrase 5B, mitochondrial	0.980	landscape →
P43165	—	0.976	P43165 →
Q9WVT6	—	0.957	Q9WVT6 →
CA14	Carbonic anhydrase 14	0.950	landscape →
Q9N0E7	—	0.936	Q9N0E7 →
Q96EN8	—	0.934	Q96EN8 →
Q5VT66	—	0.932	Q5VT66 →
Q96RR1	—	0.932	Q96RR1 →
Q8CIW5	—	0.929	Q8CIW5 →
Q14CH1	—	0.929	Q14CH1 →
KDM8	Bifunctional peptidase and arginyl-hydroxylase JMJD5	0.928	landscape →
D3ZAW2	—	0.927	D3ZAW2 →
P16015	—	0.926	P16015 →
CHKB	Choline/ethanolamine kinase	0.926	landscape →
Q8BNV1	—	0.926	Q8BNV1 →
Q58DH2	—	0.926	Q58DH2 →
Q8IZ69	—	0.925	Q8IZ69 →
O54783	—	0.925	O54783 →
Q6DC64	—	0.925	Q6DC64 →
Q91009	—	0.925	Q91009 →
Q5BIM1	—	0.925	Q5BIM1 →
Q7YRZ1	—	0.925	Q7YRZ1 →
P61797	—	0.924	P61797 →
Q7Z2E3	—	0.924	Q7Z2E3 →
Q1JP61	—	0.923	Q1JP61 →
Q920N2	—	0.923	Q920N2 →
O15315	—	0.923	O15315 →