Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | CYTH3 | O43739 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31436946 | 1.00 | HTT (0.80) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL427418 | 0.85 | HTT (0.67) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL2189558 | 0.85 | HTT (0.70) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL3118987 | 0.84 | KMT2A (0.63) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL5803518 | 0.83 | ALDH1A1 (0.66) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL31436924 | 0.82 | ALDH1A1 (0.65) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL3808080 | 0.82 | ALDH1A1 (0.65) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL4320215 | 0.81 | HTT (0.68) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL11332313 | 0.81 | KMT2A (0.71) | HTTALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL4320209 | 0.81 | HTT (0.68) | HTTALDH1A1KMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940894-B2 | Aminothiazole compounds as kinase inhibitors and methods of using the same | AB SCIENCE (FR) | 2015-01-27 | — | — | US | disclosed |
| US-8940894-B2 | Aminothiazole compounds as kinase inhibitors and methods of using the same | AB SCIENCE (FR) | 2015-01-27 | — | — | US | disclosed |
| EP-2366703-B1 | Polymorph form of 2-amino (nitroaryl) thiazole derivative | AB SCIENCE (FR) | 2014-07-30 | — | — | EP | disclosed |
| EP-2366703-B1 | Polymorph form of 2-amino (nitroaryl) thiazole derivative | AB SCIENCE (FR) | 2014-07-30 | — | — | EP | disclosed |
| US-20130289045-A1 | AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USING THE SAME | AB SCIENCE (FR) | 2013-10-31 | — | — | US | disclosed |
| US-20130289045-A1 | AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USING THE SAME | AB SCIENCE (FR) | 2013-10-31 | — | — | US | disclosed |
| CN-103342701-A | 2-Aminothiazole compound polycrystalline type as kinase inhibitors and preparation method thereof | AB SCIENCE | 2013-10-09 | — | — | CN | disclosed |
| US-8492545-B2 | Aminothiazole compounds as kinase inhibitors and methods of using the same | AB SCIENCE (FR) | 2013-07-23 | — | — | US | disclosed |
| US-8492545-B2 | Aminothiazole compounds as kinase inhibitors and methods of using the same | AB SCIENCE (FR) | 2013-07-23 | — | — | US | disclosed |
| CN-101657446-B | Method for synthesizing 2-aminothiazole compounds as kinase inhibitors | AB SCIENCE | 2013-05-15 | — | — | CN | disclosed |
| US-20120196871-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2012-08-02 | — | — | US | disclosed |
| US-8153792-B2 | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors | AB SCIENCE (FR) | 2012-04-10 | — | — | US | disclosed |
| EP-2366703-A1 | Polymorph form of 2-amino (nitroaryl) thiazole derivative | AB Science (FR) | 2011-09-21 | — | — | EP | disclosed |
| EP-2118099-B1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2011-07-06 | — | — | EP | disclosed |
| EP-2118099-B1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2011-07-06 | — | — | EP | disclosed |
| US-20100121063-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2010-05-13 | — | — | US | disclosed |
| US-20100121063-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2010-05-13 | — | — | US | disclosed |
| CN-101657446-A | Method for synthesizing 2-aminothiazole compounds as kinase inhibitors | SCIENCE FR AB | 2010-02-24 | — | — | CN | disclosed |
| EP-2118099-A2 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB Science (FR) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098949-A2 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121063-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | ABL1, ABL2, KIT | HTT 3093/4885ALDH1A1 638/4885KMT2A 291/4885 |
| US-20120196871-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | ABL1, ABL2, ALK | HTT 2871/4885ALDH1A1 811/4885KMT2A 268/4885 |
| US-20130289045-A1 | AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHODS OF USING THE SAME | ABL1, ABL2, ALK | HTT 2963/4885ALDH1A1 813/4885KMT2A 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.