Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 3/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10954441 | 1.00 | SLC7A5 (0.45) | SLC7A5TET2ANPEPRNPEPDNPEP | |
| Hydrochloric Acid SCHEMBL10790535 | 0.98 | SLC7A5 (0.44) | SLC7A5TET2ANPEPRNPEPDNPEP | |
| Hydrochloric Acid SCHEMBL3178894 | 0.98 | SLC7A5 (0.44) | SLC7A5TET2ANPEPRNPEPDNPEP | |
| SCHEMBL8021280 | 0.84 | GAA (0.45) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| SCHEMBL8021278 | 0.84 | GAA (0.45) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| Hydrochloric Acid SCHEMBL9807062 | 0.83 | GAA (0.44) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| Bromide SCHEMBL9807038 | 0.83 | GAA (0.44) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| SCHEMBL24491202 | 0.81 | SLC7A5 (0.48) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| SCHEMBL6047667 | 0.81 | SLC7A5 (0.54) | SLC7A5ANPEPRNPEPDNPEPLARS1 | |
| SCHEMBL5270305 | 0.81 | SLC7A5 (0.48) | SLC7A5ANPEPRNPEPDNPEPLARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572368-B2 | Inhibitors of histone deacetylase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-02-07 | — | — | US | disclosed |
| CN-110193086-B | LA-GFLG-DOX conjugate and preparation method and application thereof | 首都医科大学 | 2022-09-02 | — | — | CN | disclosed |
| US-11377423-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-20210177781-A9 | COMBINATION OF A SELECTIVE HISTONE DEACETYLASE 3 (HDAC3) INHIBITOR AND AN IMMUNOTHERAPY AGENT FOR THE TREATMENT OF CANCER | KDAc Therapeutics, Inc. | 2021-06-17 | — | — | US | disclosed |
| EP-2877444-B1 | INHIBITORS OF HISTONE DEACETYLASE | BROAD INST INC (US) | 2020-09-02 | — | — | EP | disclosed |
| US-10662199-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | THE BROAD INSTITUTE, INC. (US) | 2020-04-21 | — | — | US | disclosed |
| EP-2701699-B1 | INHIBITORS OF HISTONE DEACETYLASE | BROAD INST INC (US) | 2019-10-16 | — | — | EP | disclosed |
| US-10421778-B2 | Isoform-selective lysine deacetylase inhibitors | WASHINGTON UNIVERSITY (US) | 2019-09-24 | — | — | US | disclosed |
| US-20190216754-A1 | COMBINATION OF A SELECTIVE HISTONE DEACETYLASE 3 (HDAC3) INHIBITOR AND AN IMMUNOTHERAPY AGENT FOR THE TREATMENT OF CANCER | KDAC THERAPEUTICS INC (US) | 2019-07-18 | — | — | US | disclosed |
| US-20150191427-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL (US) | 2015-07-09 | — | — | US | disclosed |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | THE BROAD INSTITUTE, INC. (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140080802-A1 | Inhibitors of Histone Deacetylase | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2014-03-20 | — | — | US | disclosed |
| US-20140080800-A1 | Inhibitors of Histone Deacetylase | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2014-03-20 | — | — | US | disclosed |
| WO-2013067391-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | THE BROAD INSTITUTE, INC. (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2012149540-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE INC (US) | 2012-11-01 | — | — | WO | disclosed |
| US-4555362-A | Method and intermediates for producing α-L-aspartyl-L-phenylalanine | G. D. SEARLE & CO. (US) | 1985-11-26 | — | — | US | disclosed |
| EP-0130464-A1 | Method and intermediates for producing alpha-L-aspartyl-L-phenylalanine | G.D. Searle & Co. (US) | 1985-01-09 | — | — | EP | disclosed |
| US-4480112-A | ARTIFICIAL SWEETENER | G. D. SEARLE & CO. (US) | 1984-10-30 | — | — | US | disclosed |
| US-4440677-A | N-ACETOACETYL-ALPHA-L-ASPARTYL-L -PHENYLALANINE METHYLESTER | G. D. SEARLE & CO. (US) | 1984-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080800-A1 | Inhibitors of Histone Deacetylase | HDAC2, HDAC1, HDAC11 | SLC7A5 3943/4885TET2 1024/4885ANPEP 4714/4885 |
| US-20210177781-A9 | COMBINATION OF A SELECTIVE HISTONE DEACETYLASE 3 (HDAC3) INHIBITOR AND AN IMMUNOTHERAPY AGENT FOR THE TREATMENT OF CANCER | HDAC3, HDAC1, HDAC7 | SLC7A5 4857/4885TET2 1131/4885ANPEP 2472/4885 |
| US-10662199-B2 | Inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC11 | SLC7A5 3943/4885TET2 1024/4885ANPEP 4714/4885 |
| US-11572368-B2 | Inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC11 | SLC7A5 3943/4885TET2 1024/4885ANPEP 4714/4885 |
| US-20190216754-A1 | COMBINATION OF A SELECTIVE HISTONE DEACETYLASE 3 (HDAC3) INHIBITOR AND AN IMMUNOTHERAPY AGENT FOR THE TREATMENT OF CANCER | HDAC3, HDAC1, HDAC7 | SLC7A5 4857/4885TET2 1131/4885ANPEP 2472/4885 |
| US-20150191427-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC3, HDAC1, HDAC5 | SLC7A5 3259/4885TET2 3362/4885ANPEP 4132/4885 |
| US-11377423-B2 | Inhibitors of histone deacetylase | HDAC3, HDAC1, HDAC11 | SLC7A5 3638/4885TET2 3215/4885ANPEP 4135/4885 |
| US-20140080802-A1 | Inhibitors of Histone Deacetylase | HDAC2, HDAC1, HDAC11 | SLC7A5 3943/4885TET2 1024/4885ANPEP 4714/4885 |
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | KDM1A, MAN2B1, KDM3A | SLC7A5 3200/4885TET2 286/4885ANPEP 177/4885 |
| US-10421778-B2 | Isoform-selective lysine deacetylase inhibitors | DOT1L, KDM1A, HDAC1 | SLC7A5 3251/4885TET2 606/4885ANPEP 2933/4885 |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | MAN2B1, KDM1A, KDM3A | SLC7A5 3352/4885TET2 344/4885ANPEP 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.