Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.46 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | APAF1 | O14727 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10959262 | 0.99 | KMT2A (0.49) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL10951819 | 0.93 | NR1I2 (0.48) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| Bromide SCHEMBL10835276 | 0.92 | NR1I2 (0.49) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL10993033 | 0.88 | NR1I2 (0.51) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL10993022 | 0.88 | NR1I2 (0.51) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL9413831 | 0.88 | NR1I2 (0.51) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL9413830 | 0.88 | NR1I2 (0.51) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL10953548 | 0.88 | NR1I2 (0.51) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL10833377 | 0.87 | NR1I2 (0.57) | KMT2ANR1I2PGRPPARGSLC22A6 | |
| SCHEMBL9643012 | 0.86 | KMT2A (0.41) | KMT2ANR1I2PGRPPARGSLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4504477-A | Cephalosporin antibiotics | GLAXO GROUP LIMITED (GB) | 1985-03-12 | — | — | US | disclosed |